(Q44625365)

English

Role of Multidrug Resistance Protein 2 (MRP2, ABCC2) in Alkylating Agent Detoxification: MRP2 Potentiates GlutathioneS-Transferase A1-1-Mediated Resistance to Chlorambucil Cytotoxicity

scientific article published on October 20, 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

Role of Multidrug Resistance Protein 2 (MRP2, ABCC2) in Alkylating Agent Detoxification: MRP2 Potentiates GlutathioneS-Transferase A1-1-Mediated Resistance to Chlorambucil Cytotoxicity (English)

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

0 references

multiple drug resistance

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

molecular medicine

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

author name string

Pamela K. Smitherman

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14569069

23 March 2024

Alan J. Townsend

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14569069

23 March 2024

Timothy E. Kute

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14569069

23 March 2024

Charles S. Morrow

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14569069

23 March 2024

language of work or name

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publication date

20 October 2003

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

full work available at URL

https://syndication.highwire.org/content/doi/10.1124/jpet.103.057729

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Journal of Pharmacology and Experimental Therapeutics

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

308

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

260-267

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

A family of drug transporters: the multidrug resistance-associated proteins.

2

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats

3

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

American Journal of Physiology

4

278

G522

publication date

2000

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

The human liver glutathione S-transferase gene superfamily: expression and chromosome mapping of an Hbsubunit cDNA

5

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Drug Metabolism and Disposition

7

15

195

publication date

1987

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Characterization of melphalan-glutathione adducts whose formation is catalyzed by glutathione transferases

8

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells

9

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Protection by transfected glutathione S-transferase isozymes against carcinogen-induced alkylation of cellular macromolecules in human MCF-7 cells

10

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT).

12

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

13

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

The ATP-dependent glutathione S-conjugate export pump

15

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.

16

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.

17

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Biochimica et Biophysica Acta

18

6

377

publication date

1999

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Biology of the multidrug resistance-associated protein, MRP.

21

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells

22

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes

23

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Significance of an unusually low Km for glutathione in glutathione transferases of the alpha, mu and pi classes

24

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Chlorambucil-monoglutathionyl conjugate is sequestered by human alpha class glutathione S-transferases

25

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Use of retroviral vectors for gene transfer and expression

26

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Multidrug resistance protein and glutathione S-transferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity.

27

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells

28

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Combined expression of multidrug resistance protein (MRP) and glutathione S-transferase P1-1 (GSTP1-1) in MCF7 cells and high level resistance to the cytotoxicities of ethacrynic acid but not oxazaphosphorines or cisplatin

29

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Role of multidrug-resistance protein 2 in glutathione S-transferase P1-1-mediated resistance to 4-nitroquinoline 1-oxide toxicities in HepG2 cells.

30

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Molecular Pharmacology

31

36

22

publication date

1989

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. Kinetics of glutathione conjugate formation and efflux govern differential cellular sensitivity to chlorambucil versus melphalan toxicit

32

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells

33

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

The basic glutathione S-transferases from human livers are products of separate genes

34

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

New colorimetric cytotoxicity assay for anticancer-drug screening

36

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa

37

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Molecular Pharmacology

38

41

230

publication date

1992

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Human liver glutathione S-transferases: complete primary sequence of an Ha subunit cDNA

39

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Glutathione conjugation as a bioactivation reaction

40

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Biological interactions of alpha,beta-unsaturated aldehydes

41

1 reference

10.1124/JPET.103.057729

https://api.crossref.org/works/10.1124/JPET.103.057729

23 March 2024

Identifiers

10.1124/JPET.103.057729

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 December 2017

ResearchGate publication ID

0 references

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