(Q44650618)

English

Anti-Inflammatory Potential of the Selective Phosphodiesterase 4 InhibitorN-(3,5-Dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic Acid Amide (AWD 12-281), in Human Cell Preparations

scientific article published on November 10, 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 December 2017

Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

Anti-Inflammatory Potential of the Selective Phosphodiesterase 4 InhibitorN-(3,5-Dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic Acid Amide (AWD 12-281), in Human Cell Preparations (English)

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

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1 reference

based on heuristic

inferred from title

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

molecular medicine

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

author name string

Regina Draheim

1

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

Ute Egerland

2

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

Chris Rundfeldt

3

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Europe PubMed Central

PubMed publication ID

5 December 2017

language of work or name

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publication date

10 November 2003

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Europe PubMed Central

PubMed publication ID

5 December 2017

full work available at URL

https://syndication.highwire.org/content/doi/10.1124/jpet.103.059097

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Journal of Pharmacology and Experimental Therapeutics

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Europe PubMed Central

PubMed publication ID

5 December 2017

308

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Europe PubMed Central

PubMed publication ID

5 December 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

555-563

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

Therapy of chronic obstructive pulmonary disease

2

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Mucosal and systemic inflammatory changes in allergic rhinitis and asthma: a comparison between upper and lower airways.

4

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs

5

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Anti-allergic activity of H1 blockers

6

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Inhaled and nasal corticosteroids: factors affecting the risks of systemic adverse effects

8

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Cilomilast, a selective phosphodiesterase-4 inhibitor for treatment of patients with chronic obstructive pulmonary disease: a randomised, dose-ranging study

10

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

In vitro interleukin-5 production of peripheral blood mononuclear cells is increased in patients with asthma

12

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease

13

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3

14

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system

19

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Inhibition of cytokine production from human peripheral blood leukocytes by anti-allergic agents in vitro

21

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

In vivo efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration

24

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Protection from pulmonary fibrosis in leukotriene-deficient mice

26

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter

27

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Asthma: future directions

28

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Modulation of TNF and GM-CSF release from dispersed human nasal polyp cells and human whole blood by inhibitors of different PDE isoenzymes and glucocorticoids

29

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Update on the therapeutic potential of PDE4 inhibitors

30

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.

33

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

34

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

35

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Phosphodiesterase isozymes: molecular targets for novel antiasthma agents

36

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair.

38

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Phosphodiesterase expression in human epithelial cells

39

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.

40

1 reference

10.1124/JPET.103.059097

https://api.crossref.org/works/10.1124/JPET.103.059097

31 March 2024

Identifiers

10.1124/JPET.103.059097

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

ResearchGate publication ID

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