(Q44654372)

English

Pharmacokinetic and pharmacodynamic profiles of BIA 3-202, a novel catechol-O-methyltransferase (COMT) inhibitor, during multiple-dose administration to healthy subjects.

scientific article published in December 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14615471%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

Pharmacokinetic and pharmacodynamic profiles of BIA 3-202, a novel catechol-O-methyltransferase (COMT) inhibitor, during multiple-dose administration to healthy subjects (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14615471%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

Patrício Soares-da-Silva

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14615471%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14615471%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

author name string

Luis Almeida

1

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

publication date

1 December 2003

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14615471%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

The Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14615471%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

43

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14615471%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

12

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14615471%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

1350-1360

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14615471%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

An algorithm (decision tree) for the management of Parkinson's disease (2001): treatment guidelines

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

COMT inhibition: a new treatment strategy for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

New, selective catechol-O-methyltransferase inhibitors as therapeutic agents in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Comparative tolerability of the newer generation antiparkinsonian agents

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Long-term comparative experience with tolcapone and entacapone in advanced Parkinson's disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitor.

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

BIA 3-202, a novel catechol-O-methyltransferase inhibitor, reduces the peripheral O-methylation of L-DOPA and enhances its availability to the brain

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone).

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Pharmacokinetics and pharmacodynamics of BIA 3-202, a novel COMT inhibitor, during first administration to humans

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Determination of catechol-O-methyltransferase activity in erythrocytes by high performance liquid chromatography with electrochemical detection

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Ontogenic aspects of liver and kidney catechol-O-methyltransferase sensitivity to tolcapone

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Molecular modeling and metabolic studies of the interaction of catechol-O-methyltransferase and a new nitrocatechol inhibitor

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Multiple-dose clinical pharmacology of the catechol-O-methyl-transferase inhibitor tolcapone in elderly subjects

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Pharmacokinetic-pharmacodynamic interaction between the COMT inhibitor tolcapone and single-dose levodopa

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Kinetics of rat brain and liver solubilized membrane-bound catechol-O-methyltransferase.

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Pharmacokinetics of Levodopa

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Chronopharmacokinetics. Current status

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone

1 reference

https://api.crossref.org/works/10.1177%2F0091270003258666

21 January 2018

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