(Q44683780)

5 December 2017

Hypoxia increases Hsp90 binding to eNOS via PI3K-Akt in porcine coronary artery endothelium (English)

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5 December 2017

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Jian-xiong Chen

1

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PubMed ID

14661033

5 December 2017

Barbara Meyrick

series ordinal

2

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5 December 2017

1 February 2004

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5 December 2017

Laboratory Investigation

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5 December 2017

84

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5 December 2017

2

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5 December 2017

182-190

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https://scigraph.springernature.com/pub.10.1038/labinvest.3700027

5 December 2017

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cites work

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Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells

21 January 2018

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Nitric oxide is a mediator of hypoxic coronary vasodilatation. Relation to adenosine and cyclooxygenase-derived metabolites

21 January 2018

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Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1

21 January 2018

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Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae

21 January 2018

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Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells

21 January 2018

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Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo

21 January 2018

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Dynamic activation of endothelial nitric oxide synthase by Hsp90.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Phosphatidylinositol 3-kinase may mediate isoproterenol-induced vascular relaxation in part through nitric oxide production

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats

21 January 2018

1 reference

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Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

The Akt kinase signals directly to endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

A synthetic inhibitor of the mitogen-activated protein kinase cascade

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Nitric oxide donors regulate nitric oxide synthase in bovine pulmonary artery endothelium

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Therapeutic modification of the L-arginine-eNOS pathway in cardiovascular diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Heat-induced chaperone activity of HSP90.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Role of heat shock protein 90 in bradykinin-stimulated endothelial nitric oxide release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

Chronic hypoxia increases the NO contribution of acetylcholine vasodilation of the fetal guinea pig heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

7 January 2021

Moderate hypoxia increases heat shock protein 90 expression in excised rat aorta

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

7 January 2021

Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

7 January 2021

Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

7 January 2021

Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

7 January 2021

Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

7 January 2021

Chaperone function of Hsp90-associated proteins

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

7 January 2021

Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

7 January 2021

Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700027

7 January 2021

10.1038/LABINVEST.3700027

Identifiers

DOI

1 reference

5 December 2017

1 reference

PubMed ID

14661033