(Q44714535)

English

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity

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Europe PubMed Central

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5 December 2017

The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity (English)

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Europe PubMed Central

PubMed publication ID

5 December 2017

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long QT syndrome

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author name string

Weihua Song

1

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Europe PubMed Central

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5 December 2017

Yucheng Xiao

2

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Europe PubMed Central

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5 December 2017

Hanying Chen

3

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Europe PubMed Central

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5 December 2017

Nicole M Ashpole

4

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Europe PubMed Central

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5 December 2017

Andrew D Piekarz

5

1 reference

Europe PubMed Central

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5 December 2017

Peilin Ma

6

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Europe PubMed Central

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5 December 2017

Andy Hudmon

7

1 reference

Europe PubMed Central

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5 December 2017

Theodore R Cummins

8

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5 December 2017

Weinian Shou

9

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5 December 2017

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publication date

23 July 2012

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Europe PubMed Central

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5 December 2017

Journal of Physiology

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Europe PubMed Central

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5 December 2017

590

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Europe PubMed Central

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5 December 2017

20

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Europe PubMed Central

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5 December 2017

5123-5139

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

Cardiac sodium channelopathies

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Lidocaine block of LQT-3 mutant human Na+ channels

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Functional consequences of lidocaine binding to slow-inactivated sodium channels

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

On the molecular nature of the lidocaine receptor of cardiac Na+ channels. Modification of block by alterations in the alpha-subunit III-IV interdomain

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Molecular mechanism for an inherited cardiac arrhythmia

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Acute effects of thyroid hormone on sodium currents in neonatal myocytes

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Block of wild-type and inactivation-deficient cardiac sodium channels IFM/QQQ stably expressed in mammalian cells

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

The genetic basis of long QT and short QT syndromes: a mutation update

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

The NEURON simulation environment

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Sodium channel inactivation in heart: a novel role of the carboxy-terminal domain

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Phenotypic overlap of cardiac sodium channelopathies: individual-specific or mutation-specific?

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Functional modulation of human brain Nav1.3 sodium channels, expressed in mammalian cells, by auxiliary beta 1, beta 2 and beta 3 subunits

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Amino acid residues required for fast Na(+)-channel inactivation: charge neutralizations and deletions in the III-IV linker

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Trafficking defects and gating abnormalities of a novel SCN5A mutation question gene-specific therapy in long QT syndrome type 3.

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

A persistent sodium current in rat ventricular myocytes

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Sodium Channel Molecular Conformations and Antiarrhythmic Drug Affinity

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Cardiac sodium channel dysfunction in sudden infant death syndrome.

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Pharmacological targeting of long QT mutant sodium channels

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Block of inactivation-deficient Na+ channels by local anesthetics in stably transfected mammalian cells: evidence for drug binding along the activation pathway

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac sodium channel

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

A novel SCN5A mutation associated with the linker between III and IV domains of Nav1.5 in a neonate with fatal long QT syndrome.

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497567

3 November 2018

Electrophysiological properties of neonatal rat ventricular myocytes with alpha1-adrenergic-induced hypertrophy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497567

3 November 2018

Mechanism of lidocaine block of late current in long Q-T mutant Na+ channels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497567

3 November 2018

Molecular mechanisms of local anesthesia: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497567

3 November 2018

Structural parts involved in activation and inactivation of the sodium channel

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2012.235374

21 January 2018

Gating Properties of SCN5A Mutations and the Response to Mexiletine in Long-QT Syndrome Type 3 Patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22826127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCN5A overlap syndromes: no end to disease complexity?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22826127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of an intracellular peptide segment involved in sodium channel inactivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22826127

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1113/JPHYSIOL.2012.235374

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 December 2017

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