(Q44753959)

English

Ablating CAR and integrin binding in adenovirus vectors reduces nontarget organ transduction and permits sustained bloodstream persistence following intraperitoneal administration

scientific article published in February 2004

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Ablating CAR and integrin binding in adenovirus vectors reduces nontarget organ transduction and permits sustained bloodstream persistence following intraperitoneal administration (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

1 reference

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inferred from title

author name string

Masaki Akiyama

1

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Stephen Thorne

2

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

David Kirn

3

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Peter W Roelvink

4

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

David A Einfeld

5

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

C Richter King

6

1 reference

Europe PubMed Central

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6 December 2017

Thomas J Wickham

7

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Europe PubMed Central

PubMed publication ID

6 December 2017

publication date

1 February 2004

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Europe PubMed Central

PubMed publication ID

6 December 2017

Molecular Therapy

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Europe PubMed Central

PubMed publication ID

6 December 2017

9

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Europe PubMed Central

PubMed publication ID

6 December 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

218-230

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Europe PubMed Central

PubMed publication ID

6 December 2017

Efficacy of a replication-selective adenovirus against ovarian carcinomatosis is dependent on tumor burden, viral replication and p53 status

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Targeted tumor killing via an intracellular antibody against erbB-2.

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Intraperitoneal gene therapy with adenoviral-mediated p53 tumor suppressor gene for ovarian cancer model in nude mouse

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The effects of the adenovirus-mediated wild-type p53 delivery in human epithelial ovarian cancer cell line in vitro and in vivo

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A newly developed adenovirus-mediated transfer of a wild-type p53 gene increases sensitivity to cis-diamminedichloroplatinum (II) in p53-deleted ovarian cancer cells

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Comparison of long-term survival of cytomegalovirus promotre versus Rous Sarcoma virus promoter-driven thymidine kinase gene therapy in nude mice bearing human ovarian cancer

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Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas

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A phase I study of recombinant adenovirus vector-mediated intraperitoneal delivery of herpes simplex virus thymidine kinase (HSV-TK) gene and intravenous ganciclovir for previously treated ovarian and extraovarian cancer patients

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A phase I study of recombinant adenovirus vector-mediated delivery of an anti-erbB-2 single-chain (sFv) antibody gene for previously treated ovarian and extraovarian cancer patients

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A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancer

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Long term follow-up of patients with recurrent ovarian cancer after Ad p53 gene replacement with SCH 58500

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Transductional efficacy and safety of an intraperitoneally delivered adenovirus encoding an anti-erbB-2 intracellular single-chain antibody for ovarian cancer gene therapy

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Adenovirus-mediated thymidine kinase gene therapy for recurrent ovarian cancer: expression of coxsackie-adenovirus receptor and integrins αvβ3 and αvβ5

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Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-year follow-up.

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Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer

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Ligand-directed targeting of genes to the site of disease

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Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5

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HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses

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Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

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Heparan sulfate glycosaminoglycans are receptors sufficient to mediate the initial binding of adenovirus types 2 and 5.

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Heparan sulfate glycosaminoglycans are involved in adenovirus type 5 and 2-host cell interactions

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An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression

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Targeting adenoviral vectors by using the extracellular domain of the coxsackie-adenovirus receptor: improved potency via trimerization

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7 January 2021

Enhancement of the adenoviral sensitivity of human ovarian cancer cells by transient expression of coxsackievirus and adenovirus receptor (CAR).

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7 January 2021

Coxsackievirus-adenovirus receptor expression in ovarian cancer cell lines is associated with increased adenovirus transduction efficiency and transgene expression

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7 January 2021

The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells

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7 January 2021

Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses

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An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches

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Using a tropism-modified adenoviral vector to circumvent inhibitory factors in ascites fluid

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Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR

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Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein

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Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae

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Molecular determinants of adenovirus serotype 5 fibre binding to its cellular receptor CAR.

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Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions

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CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors

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Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism

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In vivo hepatic adenoviral gene delivery occurs independently of the coxsackievirus-adenovirus receptor

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Simultaneous CAR- and alpha V integrin-binding ablation fails to reduce Ad5 liver tropism

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Reduction of natural adenovirus tropism to the liver by both ablation of fiber-coxsackievirus and adenovirus receptor interaction and use of replaceable short fiber

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Subgroup B and F fiber chimeras eliminate normal adenovirus type 5 vector transduction in vitro and in vivo

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Dependence of adenovirus infectivity on length of the fiber shaft domain

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Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice

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Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver

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inferred from DOI database lookup

Mutations in the DG loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR.

1 reference

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Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ

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based on heuristic

inferred from DOI database lookup

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10.1016/J.YMTHE.2003.10.010

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

ResearchGate publication ID

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