(Q44795484)

English

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.

scientific article published in March 2004

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scholarly article

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Europe PubMed Central

6 December 2017

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

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Alzheimer's disease

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0 references

1 reference

based on heuristic

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author name string

Emmanuel Planel

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

Tomohiro Miyasaka

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

Thomas Launey

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

De-Hua Chui

4

1 reference

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12 May 2020

Kentaro Tanemura

5

1 reference

Europe PubMed Central

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12 May 2020

Shinji Sato

6

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

Ohoshi Murayama

7

1 reference

Europe PubMed Central

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12 May 2020

Koichi Ishiguro

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

Yoshitaka Tatebayashi

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

Akihiko Takashima

10

1 reference

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12 May 2020

language of work or name

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publication date

1 March 2004

1 reference

Europe PubMed Central

6 December 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

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12 May 2020

24

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

2401-2411

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Starvation induces tau hyperphosphorylation in mouse brain: implications for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diminished neuronal metabolic activity in Alzheimer's disease. Review article

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Body temperature as a risk factor for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-induced hyperphosphorylation of tau in the mouse brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of serine/threonine protein phosphatase in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of mitogen-activated protein kinase pathways in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypothermia in mice tested in Morris water maze

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: prevention by NGF and bFGF

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1Carbohydrate metabolism in vivo: Regulation of the blood glucose level

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tissue-specific expression of mRNAs encoding alpha- and beta-catalytic subunits of protein phosphatase 2A

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of hypothermia in elderly patients with diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo glucose utilization in rat tissues during the three phases of starvation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes mellitus and thermoregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebellar glucose consumption in normal and pathologic states using fluorine-FDG and PET.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymic and cerebral metabolic effects of 2-deoxy-D-glucose

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Body temperatures in the elderly: a national study of physiological, social, and environmental conditions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-induced hypoglycemic coma and regional cerebral energy metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional CNS levels of acetylcholine and choline during hypoglycemic stupor and recovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid reversible phosphorylation of rat brain tau proteins in response to cold water stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paired helical filament tau in Alzheimer's disease. The kinase connection

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and distribution of axonal dystrophic neurites in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoglycaemia: brain neurochemistry and neuropathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphoprotein phosphatase activities in Alzheimer disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional cerebral glucose metabolism and postmortem pathology in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of phosphorylation of tau with antibodies specific for phosphorylation sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of dementia among persons with diabetes mellitus: a population-based cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cerebellum in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Greater metabolic rate decreases in hippocampal formation and proisocortex than in neocortex in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of tau, Abeta-formation, and apoptosis after in vivo inhibition of PP-1 and PP-2A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical imaging of Alzheimer's disease and other degenerative dementias

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Okadaic acid-stimulated degradation of p35, an activator of CDK5, by proteasome in cultured neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15014115

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5561-03.2004

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729502&resulttype=core&format=json

12 May 2020

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