(Q44811440)

English

Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats.

scientific article published in August 2004

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scholarly article

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26 December 2019

Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats (English)

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26 December 2019

Parkinson's disease

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Roberto Coccurello

1

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26 December 2019

Marianne Amalric

3

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26 December 2019

author name string

Nathalie Breysse

2

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26 December 2019

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1 August 2004

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26 December 2019

Neuropsychopharmacology

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26 December 2019

29

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26 December 2019

8

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26 December 2019

1451-1461

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26 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.npp.1300444

0 references

The functional anatomy of basal ganglia disorders

1 reference

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21 January 2018

[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization

1 reference

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21 January 2018

Adenosine A(2A) receptor antagonist treatment of Parkinson's disease

1 reference

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21 January 2018

The group II metabotropic glutamate receptor agonist, DCG-IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine-treated rat

1 reference

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21 January 2018

Primate models of movement disorders of basal ganglia origin

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21 January 2018

Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors.

1 reference

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21 January 2018

Adenosine A2A receptor antagonism potentiates L-DOPA-induced turning behaviour and c-fos expression in 6-hydroxydopamine-lesioned rats.

1 reference

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21 January 2018

Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

1 reference

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21 January 2018

Adenosine A2A and group I metabotropic glutamate receptors synergistically modulate the binding characteristics of dopamine D2 receptors in the rat striatum.

1 reference

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21 January 2018

DARPP-32: regulator of the efficacy of dopaminergic neurotransmission

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21 January 2018

Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum

1 reference

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21 January 2018

Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys.

1 reference

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21 January 2018

Lack of tolerance to motor stimulant effects of a selective adenosine A(2A) receptor antagonist

1 reference

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21 January 2018

Motor effects induced by a blockade of adenosine A2A receptors in the caudate-putamen.

1 reference

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21 January 2018

Catalepsy induced by a blockade of dopamine D1 or D2 receptors was reversed by a concomitant blockade of adenosine A(2A) receptors in the caudate-putamen of rats

1 reference

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21 January 2018

Randomized trial of the adenosine A(2A) receptor antagonist istradefylline in advanced PD.

1 reference

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21 January 2018

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

1 reference

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21 January 2018

8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo

1 reference

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21 January 2018

Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats.

1 reference

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21 January 2018

LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats.

1 reference

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21 January 2018

Adenosine A2 receptors: selective localization in the human basal ganglia and alterations with disease

1 reference

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21 January 2018

Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP

1 reference

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21 January 2018

Adenosine A2a receptor modulation of electrically evoked endogenous GABA release from slices of rat globus pallidus.

1 reference

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21 January 2018

Adenosine A2 receptors interact negatively with dopamine D1 and D2 receptors in unilaterally 6-hydroxydopamine-lesioned rats.

1 reference

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21 January 2018

Adenosine A(2a) receptor antagonists: potential therapeutic and neuroprotective effects in Parkinson's disease

1 reference

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21 January 2018

Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling

1 reference

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21 January 2018

Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats

1 reference

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21 January 2018

Quantitative immunocytochemistry of DARPP-32-expressing neurons in the rat caudatoputamen.

1 reference

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21 January 2018

The selective mGlu(5) receptor agonist CHPG inhibits quinpirole-induced turning in 6-hydroxydopamine-lesioned rats and modulates the binding characteristics of dopamine D(2) receptors in the rat striatum: interactions with adenosine A(2a) receptors

1 reference

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21 January 2018

Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson's disease and related disorders

1 reference

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21 January 2018

Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study.

1 reference

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21 January 2018

GABA(B) and group I metabotropic glutamate receptors in the striatopallidal complex in primates

1 reference

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21 January 2018

Distribution, biochemistry and function of striatal adenosine A2A receptors

1 reference

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21 January 2018

Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons.

1 reference

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21 January 2018

Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons.

1 reference

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21 January 2018

The role of metabotropic glutamate receptor (mGluR) ligands in parkinsonian muscle rigidity

1 reference

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21 January 2018

Electrophysiological and behavioural evidence for an antagonistic modulatory role of adenosine A2Areceptors in dopamine D2receptor regulation in the rat dopamine-denervated striatum

1 reference

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21 January 2018

Complex deficits on reaction time performance following bilateral intrastriatal 6-OHDA infusion in the rat

1 reference

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7 January 2021

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Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.

1 reference

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7 January 2021

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Metabotropic glutamate 5 receptor blockade alleviates akinesia by normalizing activity of selective basal-ganglia structures in parkinsonian rats.

1 reference

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7 January 2021

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Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism.

1 reference

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7 January 2021

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Effect of adenosine A2A receptor stimulation on GABA release from the striatum of young and aged rats in vivo

1 reference

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7 January 2021

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Adenosine A2 receptor-mediated modulation of contralateral rotation induced by metabotropic glutamate receptor activation

1 reference

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7 January 2021

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Reaction time deficits and Parkinson's disease

1 reference

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7 January 2021

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Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography.

1 reference

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7 January 2021

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Adenosine A2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys

1 reference

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7 January 2021

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Adenosine A2a receptor-mediated modulation of striatal [3H]GABA and [3H]acetylcholine release.

1 reference

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7 January 2021

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Blockade of A2aAdenosine Receptors Positively Modulates Turning Behaviour and c-Fos Expression Induced by D1Agonists in Dopamine-denervated Rats

1 reference

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7 January 2021

based on heuristic

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Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.NPP.1300444

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15039773%20AND%20SRC:MED&resulttype=core&format=json

26 December 2019

1 reference

Europe PubMed Central

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26 December 2019

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