(Q44907823)

7 December 2017

title

A caspase-8-independent signaling pathway activated by Fas ligation leads to exposure of the Bak N terminus (English)

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7 December 2017

Lilin Zhang

1

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7 December 2017

Shigeomi Shimizu

2

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7 December 2017

Kazuhiro Sakamaki

3

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7 December 2017

Shin Yonehara

4

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7 December 2017

Yoshihide Tsujimoto

5

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7 December 2017

language of work or name

English

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publication date

24 May 2004

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Journal of Biological Chemistry

7 December 2017

published in

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7 December 2017

volume

279

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7 December 2017

issue

32

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7 December 2017

page(s)

33865-33874

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Apoptosis: letting slip the dogs of war.

7 December 2017

cites work

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Cell death: critical control points

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

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Two CD95 (APO-1/Fas) signaling pathways

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 January 2018

1 reference

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Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

21 January 2018

1 reference

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Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

21 January 2018

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Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

21 January 2018

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Regulated targeting of BAX to mitochondria.

21 January 2018

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Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

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VDAC2 inhibits BAK activation and mitochondrial apoptosis

21 January 2018

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Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak.

21 January 2018

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

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Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

21 January 2018

1 reference

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Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity

21 January 2018

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Caspase-independent cell killing by Fas-associated protein with death domain

21 January 2018

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Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

21 January 2018

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Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

21 January 2018

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BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

21 January 2018

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

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Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

21 January 2018

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Fas—Beyond Death: A regenerative role for Fas in the nervous system

21 January 2018

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Daxx, a novel Fas-binding protein that activates JNK and apoptosis

21 January 2018

1 reference

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

1 reference

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Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403499200

Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M403499200

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

21 January 2018

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FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M403499200

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7 December 2017

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