(Q44916253)

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Mechanism-based suppression of dideoxynucleotide resistance by K65R human immunodeficiency virus reverse transcriptase using an alpha-boranophosphate nucleoside analogue.

scientific article

Mechanism-based Suppression of Dideoxynucleotide Resistance by K65R Human Immunodeficiency Virus Reverse Transcriptase Using an α-Boranophosphate Nucleoside Analogue

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12 November 2019

Mechanism-based suppression of dideoxynucleotide resistance by K65R human immunodeficiency virus reverse transcriptase using an alpha-boranophosphate nucleoside analogue (English)

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12 November 2019

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12 November 2019

author name string

Selmi B

1

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12 November 2019

Boretto J

2

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12 November 2019

Sarfati SR

3

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12 November 2019

Guerreiro C

4

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12 November 2019

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publication date

17 October 2001

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12 November 2019

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7

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Journal of Biological Chemistry

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12 November 2019

276

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12 November 2019

51

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12 November 2019

48466-48472

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12 November 2019

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Suppression of resistance to drugs targeted to human immunodeficiency virus reverse transcriptase by combination therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Resistance to 2',3'-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor abacavir (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

HIV-1 reverse transcriptase (RT) genotype and susceptibility to RT inhibitors during abacavir monotherapy and combination therapy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2',3'-dideoxycytidine 5'-triphosphate and other drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Mutational analysis of Lys65 of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

An integrated system to study multiply substituted human immunodeficiency virus type 1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Structural basis for activation of α-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

The valine-to-threonine 75 substitution in human immunodeficiency virus type 1 reverse transcriptase and its relation with stavudine resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Human immunodeficiency virus reverse transcriptase: steady-state and pre-steady-state kinetics of nucleotide incorporation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Slow rate of phosphodiester bond formation accounts for the strong bias that Taq DNA polymerase shows against 2',3'-dideoxynucleotide terminators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M107003200

21 January 2018

Identifiers

10.1074/JBC.M107003200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606579%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11606579%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

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