(Q44923495)

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Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains.

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30 December 2019

Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains (English)

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30 December 2019

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Richard T Marconi

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30 December 2019

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Christopher G Earnhart

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30 December 2019

Eric L Buckles

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30 December 2019

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30 December 2019

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30 December 2019

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30 December 2019

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30 December 2019

Lyme disease-a tick-borne spirochetosis?

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Spirochetes Isolated from the Blood of Two Patients with Lyme Disease

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The prevalence and incidence of clinical and asymptomatic Lyme borreliosis in a population at risk

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Erythema chronicum migrans and Lyme arthritis. The enlarging clinical spectrum

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Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities

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Elucidation of Lyme arthritis

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Central nervous system Lyme disease

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Neurologic aspects of Lyme disease

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The cost effectiveness of vaccinating against Lyme disease

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The cost-effectiveness of vaccination against Lyme disease.

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Structure-based Design of a Second-generation Lyme Disease Vaccine Based on a C-terminal Fragment of Borrelia burgdorferi OspA

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An effective second-generation outer surface protein A-derived Lyme vaccine that eliminates a potentially autoreactive T cell epitope

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Analysis of Borrelia burgdorferi gene expression during life cycle phases of the tick vector Ixodes scapularis.

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Induction of an outer surface protein on Borrelia burgdorferi during tick feeding

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Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22 kDa protein (pC) in Escherichia coli

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Transcriptional analyses and mapping of the ospC gene in Lyme disease spirochetes

1 reference

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7 January 2021

Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi

1 reference

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7 January 2021

A DNA vaccine encoding the outer surface protein C from Borrelia burgdorferi is able to induce protective immune responses

1 reference

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7 January 2021

C-terminal region of outer surface protein C binds borreliacidal antibodies in sera from patients with Lyme disease

1 reference

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7 January 2021

Borreliacidal antibody production against outer surface protein C of Borrelia burgdorferi

1 reference

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7 January 2021

DNA vaccines expressing a fusion product of outer surface proteins A and C from Borrelia burgdorferi induce protective antibodies suitable for prophylaxis but Not for resolution of Lyme disease

1 reference

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7 January 2021

Immunization with outer surface protein (Osp) A, but not OspC, provides cross-protection of mice challenged with North American isolates of Borrelia burgdorferi

1 reference

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7 January 2021

Multicomponent Lyme vaccine: three is not a crowd

1 reference

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7 January 2021

Evolution of the Borrelia burgdorferi outer surface protein OspC

1 reference

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7 January 2021

ospC diversity in Borrelia burgdorferi: different hosts are different niches

1 reference

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7 January 2021

Stability of Borrelia burgdorferi outer surface protein C under immune selection pressure

1 reference

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7 January 2021

Demonstration of OspC type diversity in invasive human lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response.

1 reference

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7 January 2021

Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2006.07.052

7 January 2021

Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2006.07.052

7 January 2021

Structural conservation of neurotropism-associated VspA within the variable Borrelia Vsp-OspC lipoprotein family.

1 reference

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7 January 2021

Mutation and recombination in the upstream homology box-flanked ospE-related genes of the Lyme disease spirochetes result in the development of new antigenic variants during infection

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7 January 2021

LINKER: a program to generate linker sequences for fusion proteins

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7 January 2021

Borrelia burgdorferi ospC heterogeneity among human and murine isolates from a defined region of northern Maryland and southern Pennsylvania: lack of correlation with invasive and noninvasive genotypes

1 reference

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7 January 2021

Improvements in protein secondary structure prediction by an enhanced neural network

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7 January 2021

Correlation between stability of a protein and its dipeptide composition: a novel approach for predicting in vivo stability of a protein from its primary sequence

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Genetics and regulation of chitobiose utilization in Borrelia burgdorferi

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Borreliacidal activity of saliva of the tick Amblyomma americanum

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Altered stationary-phase response in a Borrelia burgdorferi rpoS mutant

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Human neutrophil calprotectin reduces the susceptibility of Borrelia burgdorferi to penicillin

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Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background

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Localization of BmpA on the exposed outer membrane of Borrelia burgdorferi by monospecific anti-recombinant BmpA rabbit antibodies.

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Inability of outer-surface protein C (OspC)-primed mice to elicit a protective anamnestic immune response to a tick-transmitted challenge of Borrelia burgdorferi

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Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria.

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Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers

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Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypes

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Immunogenicity of a 26-valent group A streptococcal vaccine.

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Multivalent group A streptococcal vaccine designed to optimize the immunogenicity of six tandem M protein fragments

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Tetravalent neutralizing antibody response against four dengue serotypes by a single chimeric dengue envelope antigen

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Co-immunization of BALB/c mice with recombinant immunogens containing G protein fragment and chimeric CTL epitope of respiratory syncytial virus induces enhanced cellular immunity and high level of antibody response

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Identification of neutralizing epitopes on the VP2 protein of infectious bursal disease virus by phage-displayed heptapeptide library screening and synthetic peptide mapping

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Induction of broadly neutralizing antibodies against measles virus mutants using a polyepitope vaccine strategy

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Borreliacidal OspC antibodies specific for a highly conserved epitope are immunodominant in human lyme disease and do not occur in mice or hamsters

1 reference

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Comparison of isolation rate of Borrelia burgdorferi sensu lato in MKP and BSK-II medium.

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7 January 2021

Detection of Borrelia afzelii, Borrelia burgdorferi sensu stricto, Borrelia garinii and group VS116 by PCR in skin biopsies of patients with erythema migrans and acrodermatitis chronica atrophicans

1 reference

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Recombinant, octavalent group A streptococcal M protein vaccine

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Borreliacidal activity of early Lyme disease sera against complement-resistant Borrelia afzelii FEM1 wild-type and an OspC-lacking FEM1 variant.

1 reference

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Borrelia-specific interferon-gamma and interleukin-4 secretion in cerebrospinal fluid and blood during Lyme borreliosis in humans: association with clinical outcome

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SYFPEITHI: database for MHC ligands and peptide motifs

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MULTIPRED: a computational system for prediction of promiscuous HLA binding peptides

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Immunogenicity of chimeric multiple antigen peptides based on Plasmodium falciparum antigens: impact of epitope orientation.

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Tandem repeats of T helper epitopes enhance immunogenicity of fusion proteins by promoting processing and presentation.

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Differential antigenicity of recombinant polyepitope-antigens based on loop- and helix-forming B and T cell epitopes

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Aluminium compounds for use in vaccines

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Epitope-specific regulation of immunoglobulin class switching in mice immunized with malarial merozoite surface proteins

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Immunogenicity of polyepitope libraries assembled by epitope shuffling: an approach to the development of chimeric gene vaccination against malaria

1 reference

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7 January 2021

Therapeutic passive vaccination against chronic Lyme disease in mice

1 reference

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Tick factors and in vitro cultivation influence the protein profile, antigenicity and pathogenicity of a cloned Borrelia garinii isolate from Ixodes ricinus hemolymph

1 reference

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Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Conformational nature of the Borrelia burgdorferi B31 outer surface protein C protective epitope

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2006.07.052

7 January 2021

based on heuristic

inferred from DOI database lookup

An OspC-specific monoclonal antibody passively protects mice from tick-transmitted infection by Borrelia burgdorferi B31.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2006.07.052

7 January 2021

based on heuristic

inferred from DOI database lookup

Population dynamics of a naturally occurring heterogeneous mixture of Borrelia burgdorferi clones.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2006.07.052

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.VACCINE.2006.07.052

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16996663%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16996663%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

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