(Q44991610)

8 December 2017

Rad53 kinase activation-independent replication checkpoint function of the N-terminal forkhead-associated (FHA1) domain (English)

1 reference

8 December 2017

1

1 reference

8 December 2017

Nora Tenis

2

1 reference

PubMed ID

15271990

8 December 2017

Jörg Heierhorst

series ordinal

3

1 reference

PubMed ID

15271990

8 December 2017

language of work or name

English

0 references

publication date

22 July 2004

1 reference

Journal of Biological Chemistry

8 December 2017

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8 December 2017

279

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8 December 2017

39636-39644

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8 December 2017

38

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The DNA damage response: putting checkpoints in perspective

8 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

FHA domains as phospho-threonine binding modules in cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Human Mus81-associated endonuclease cleaves Holliday junctions in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Chk2 activation and phosphorylation-dependent oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Mec1p regulates Pds1p levels in S phase: complex coordination of DNA replication and mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Budding yeast Rad9 is an ATP-dependent Rad53 activating machine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

The FHA domain is a modular phosphopeptide recognition motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Structure of the FHA1 domain of yeast Rad53 and identification of binding sites for both FHA1 and its target protein Rad9

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

A central role for DNA replication forks in checkpoint activation and response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Cell cycle checkpoints: preventing an identity crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Mrc1 transduces signals of DNA replication stress to activate Rad53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

The Cdc7 protein kinase is required for origin firing during S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Characterization of the yeast Cdc7p/Dbf4p complex purified from insect cells. Its protein kinase activity is regulated by Rad53p

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

The DNA polymerase alpha-primase complex couples DNA replication, cell-cycle progression and DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

CHK2: a tumor suppressor or not?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Molecular views of recombination proteins and their control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405080200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405080200

1 reference

8 December 2017

1 reference

PubMed ID

15271990