(Q45078830)

9 December 2017

title

Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol (English)

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Manuel Rodriguez-Concepcion

9 December 2017

author

5

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9 December 2017

Oscar Besumbes

1

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9 December 2017

Susanna Sauret-Güeto

2

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9 December 2017

Michael A Phillips

3

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9 December 2017

Santiago Imperial

4

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9 December 2017

Albert Boronat

6

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9 December 2017

publication date

1 October 2004

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Biotechnology and Bioengineering

9 December 2017

published in

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9 December 2017

volume

88

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9 December 2017

issue

2

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9 December 2017

page(s)

168-175

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High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product

9 December 2017

cites work

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Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway.

21 January 2018

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Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana

21 January 2018

1 reference

Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin

21 January 2018

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1-Deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants

21 January 2018

1 reference

Improving lycopene production in Escherichia coli by engineering metabolic control

21 January 2018

1 reference

Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis

21 January 2018

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Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase

21 January 2018

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Overproduction, in Escherichia coli, of soluble taxadiene synthase, a key enzyme in the Taxol biosynthetic pathway

21 January 2018

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Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of taxol

21 January 2018

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Taxol: biosynthesis, molecular genetics, and biotechnological applications

21 January 2018

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Taxol: the chemistry and structure-activity relationships of a novel anticancer agent

21 January 2018

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Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew

21 January 2018

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21 January 2018

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Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata

21 January 2018

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1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening

21 January 2018

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Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics.

21 January 2018

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The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein

21 January 2018

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21 January 2018

Taxol biosynthetic genes

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A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis

21 January 2018

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Heterologous expression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.20237

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9 December 2017

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