(Q45129829)

English

Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation

scientific article published on 28 October 2004

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scholarly article

1 reference

Europe PubMed Central

9 December 2017

Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation (English)

1 reference

Europe PubMed Central

9 December 2017

hydroxysteroid 11-beta dehydrogenase 1

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

crystal structure

1 reference

based on heuristic

inferred from title

author name string

David J Hosfield

1

1 reference

Europe PubMed Central

9 December 2017

Yiqin Wu

2

1 reference

Europe PubMed Central

9 December 2017

Robert J Skene

3

1 reference

Europe PubMed Central

9 December 2017

Mark Hilgers

4

1 reference

Europe PubMed Central

9 December 2017

Andy Jennings

5

1 reference

Europe PubMed Central

9 December 2017

Gyorgy P Snell

6

1 reference

Europe PubMed Central

9 December 2017

Kathleen Aertgeerts

7

1 reference

Europe PubMed Central

9 December 2017

language of work or name

0 references

publication date

28 October 2004

1 reference

Europe PubMed Central

9 December 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

9 December 2017

280

1 reference

Europe PubMed Central

9 December 2017

6

1 reference

Europe PubMed Central

9 December 2017

4639-4648

1 reference

Europe PubMed Central

9 December 2017

Global and societal implications of the diabetes epidemic

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

11 beta-hydroxysteroid dehydrogenase type 1 in obesity and the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

11beta-hydroxysteroid dehydrogenase: unexpected connections

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Short-chain dehydrogenases/reductases (SDRs).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Recognition of structurally diverse substrates by type II 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

The crystal structure of 3alpha -hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Lumenal orientation and post-translational modifications of the liver microsomal 11 beta-hydroxysteroid dehydrogenase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Functional expression, characterization, and purification of the catalytic domain of human 11-beta -hydroxysteroid dehydrogenase type 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

A transgenic model of visceral obesity and the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

A fully integrated protein crystallization platform for small-molecule drug discovery

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Substructure solution with SHELXD

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Macromolecular TLS refinement in REFMAC at moderate resolutions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

ARP/wARP and automatic interpretation of protein electron density maps

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Prostaglandin F2alpha potentiates cortisol production by stimulating 11beta-hydroxysteroid dehydrogenase 1: a novel feedback loop that may contribute to human labor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Unexpectedly fast cis/trans isomerization of Xaa-Pro peptide bonds in disulfide-constrained cyclic peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Reduction of the endoplasmic reticulum accompanies the oxidative damage of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Interfacial binding of secreted phospholipases A(2): more than electrostatics and a major role for tryptophan

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

11 Beta-hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411104200

21 January 2018

Identifiers

10.1074/JBC.M411104200

1 reference

Europe PubMed Central

9 December 2017

1 reference

Europe PubMed Central

9 December 2017

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