(Q45138428)

English

Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts.

scientific article published on 4 February 2016

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scholarly article

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Europe PubMed Central

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7 March 2020

Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26850319%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

Huntington's disease

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16

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7 March 2020

Johnathon D Anderson

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author name string

Kyle D Fink

1

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7 March 2020

Peter Deng

2

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7 March 2020

Josh Gutierrez

3

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7 March 2020

Joseph S Anderson

4

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7 March 2020

Audrey Torrest

5

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7 March 2020

Anvita Komarla

6

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7 March 2020

Stefanos Kalomoiris

7

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7 March 2020

Whitney Cary

8

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7 March 2020

Johnathon D Anderson

9

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7 March 2020

William Gruenloh

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7 March 2020

Alexandra Duffy

11

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7 March 2020

Teresa Tempkin

12

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7 March 2020

Geralyn Annett

13

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7 March 2020

Vicki Wheelock

14

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7 March 2020

David J Segal

15

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7 March 2020

publication date

4 February 2016

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7 March 2020

Cell Transplantation

1 reference

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7 March 2020

25

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7 March 2020

4

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7 March 2020

677-686

1 reference

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7 March 2020

Change in MRI striatal volumes as a biomarker in preclinical Huntington's disease

1 reference

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Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

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The generation of zinc finger proteins by modular assembly.

1 reference

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21 January 2018

Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical models

1 reference

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Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs

1 reference

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Loss of normal huntingtin function: new developments in Huntington's disease research

1 reference

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Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

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Targeting DNA double-strand breaks with TAL effector nucleases

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Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

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Excitotoxic neuronal death and the pathogenesis of Huntington's disease

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21 January 2018

Making (anti-) sense out of huntingtin levels in Huntington disease

1 reference

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21 January 2018

Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition.

1 reference

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21 January 2018

Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice

1 reference

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21 January 2018

Temporal separation of aggregation and ubiquitination during early inclusion formation in transgenic mice carrying the Huntington's disease mutation

1 reference

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21 January 2018

Delivery of episomal vectors into primary cells by means of commercial transfection reagents

1 reference

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21 January 2018

Human huntingtin derived from YAC transgenes compensates for loss of murine huntingtin by rescue of the embryonic lethal phenotype

1 reference

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Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors.

1 reference

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Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial

1 reference

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Personalized gene silencing therapeutics for Huntington disease.

1 reference

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21 January 2018

Long-term tolerability of tetrabenazine in the treatment of hyperkinetic movement disorders

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21 January 2018

Multivariate clustering of progression profiles reveals different depression patterns in prodromal Huntington disease

1 reference

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21 January 2018

The relationship between impairment of voluntary movements and cognitive impairment in Huntington's disease.

1 reference

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21 January 2018

Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.

1 reference

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21 January 2018

De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks

1 reference

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21 January 2018

Krüppel-associated boxes are potent transcriptional repression domains

1 reference

https://api.crossref.org/works/10.3727%2F096368916X690863

21 January 2018

Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits

1 reference

https://api.crossref.org/works/10.3727%2F096368916X690863

21 January 2018

Dysfunction of the CNS-heart axis in mouse models of Huntington's disease

1 reference

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21 January 2018

Cardiac dysfunction in the R6/2 mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.3727%2F096368916X690863

21 January 2018

Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex

1 reference

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21 January 2018

Huntington's disease: looking beyond the movement disorder

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21 January 2018

Analysis of a very large trinucleotide repeat in a patient with juvenile Huntington's disease

1 reference

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21 January 2018

Potential function for the Huntingtin protein as a scaffold for selective autophagy

1 reference

https://api.crossref.org/works/10.3727%2F096368916X690863

21 January 2018

Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin

1 reference

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21 January 2018

Clinical and Biomarker Changes in Premanifest Huntington Disease Show Trial Feasibility: A Decade of the PREDICT-HD Study

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21 January 2018

Shortening trinucleotide repeats using highly specific endonucleases: a possible approach to gene therapy?

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https://api.crossref.org/works/10.3727%2F096368916X690863

21 January 2018

Huntington disease: natural history, biomarkers and prospects for therapeutics

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21 January 2018

Kruppel-associated box (KRAB) proteins in the adaptive immune system

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21 January 2018

In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides.

1 reference

https://api.crossref.org/works/10.3727%2F096368916X690863

21 January 2018

Silencing mutant huntingtin by adeno-associated virus-mediated RNA interference ameliorates disease manifestations in the YAC128 mouse model of Huntington's disease

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https://api.crossref.org/works/10.3727%2F096368916X690863

21 January 2018

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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21 January 2018

Nucleic Acid-Based Therapy Approaches for Huntington's Disease

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21 January 2018

Ubiquitin: a potential cerebrospinal fluid progression marker in Huntington's disease.

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21 January 2018

Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease

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21 January 2018

CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup

1 reference

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21 January 2018

The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.

1 reference

https://api.crossref.org/works/10.3727%2F096368916X690863

21 January 2018

A multicolor panel of TALE-KRAB based transcriptional repressor vectors enabling knockdown of multiple gene targets

1 reference

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21 January 2018

Skeletal muscle pathology in Huntington's disease

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21 January 2018

Right ventricular dysfunction in the R6/2 transgenic mouse model of Huntington's disease is unmasked by dobutamine

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling

1 reference

https://pubmed.ncbi.nlm.nih.gov/26850319

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/26850319

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3727/096368916X690863

1 reference

Europe PubMed Central

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1 reference

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1 reference

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7 March 2020

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