(Q45146993)

English

Progesterone attenuates corticotropin-releasing factor-enhanced but not fear-potentiated startle via the activity of its neuroactive metabolite, allopregnanolone.

scientific article published in November 2004

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scholarly article

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Europe PubMed Central

10 December 2017

Progesterone attenuates corticotropin-releasing factor-enhanced but not fear-potentiated startle via the activity of its neuroactive metabolite, allopregnanolone (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730196&resulttype=core&format=json

12 May 2020

Alexis S Hammond

3

1 reference

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12 May 2020

author name string

Donna J Toufexis

1

1 reference

Europe PubMed Central

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12 May 2020

Carrie Davis

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730196&resulttype=core&format=json

12 May 2020

Michael Davis

4

1 reference

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12 May 2020

language of work or name

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publication date

1 November 2004

1 reference

Europe PubMed Central

10 December 2017

Journal of Neuroscience

1 reference

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12 May 2020

24

1 reference

Europe PubMed Central

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12 May 2020

45

1 reference

Europe PubMed Central

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12 May 2020

10280-10287

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730196&resulttype=core&format=json

12 May 2020

Lactation-induced reduction in rats' acoustic startle is associated with changes in noradrenergic neurotransmission.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered pituitary sensitivity to corticotropin-releasing factor and arginine vasopressin participates in the stress hyporesponsiveness of lactation in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factor analysis shows that female rat behaviour is characterized primarily by activity, male rats are driven by sex and anxiety.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of sex on fear conditioning is similar for context and discrete CS in Wistar, Lewis and Fischer rat strains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroids ameliorate conditioned fear stress: an association with sigma receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progesterone regulation of the progesterone receptor in rat gonadotropes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen modulates sexually dimorphic contextual fear conditioning and hippocampal long-term potentiation (LTP) in rats(1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3alpha,5alpha-THP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sex differences in relation to conditioned fear-induced enhancement of morphine analgesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lactation alters gamma-aminobutyric acid neuronal activity in the hypothalamus and cerebral cortex in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Animal models of anxiety and depression: how are females different?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progestogen metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypothalamic and amygdaloid corticotropin-releasing hormone (CRH) and CRH receptor-1 mRNA expression in the stress-hyporesponsive late pregnant and early lactating rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of CRH and ACTH administration on plasma and brain neurosteroid levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of the progesterone receptor gene in estrogen target cells monitored by branched DNA signal amplification

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrous cycle influences the response of female rats in the elevated plus-maze test.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurobiology of early life stress: rodent studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medroxyprogesterone-induced endocrine alterations after menopause

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of short-term medroxyprogesterone acetate and micronized progesterone on glucose metabolism and lipid profiles in patients with polycystic ovary syndrome: a prospective randomized study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New directions in the development of antidepressants: the interface of neurobiology and psychiatry

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroids in depression: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantifying fear potentiated startle using absolute versus proportional increase scoring methods: implications for the neurocircuitry of fear and anxiety

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The roots of depression in adolescent girls: is menarche the key?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibiting progesterone metabolism in the hippocampus of rats in behavioral estrus decreases anxiolytic behaviors and enhances exploratory and antinociceptive behaviors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxytocin links mothering received, mothering bestowed and adult stress responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of MPA and MPA + TU on the rat spermatogenesis and sexual hormones

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of pulsatile luteinizing hormone secretion but not luteinizing hormone surge in leptin resistant obese Zucker rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pups Presence Eliminates the Stress Hyporesponsiveness of Early Lactating Females to a Psychological Stress Representing a Threat to the Pups

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allopregnanolone serum levels and expression of 5α-reductase and 3α-hydroxysteroid dehydrogenase isoforms in hippocampal and temporal cortex of patients with epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain mechanisms underlying emotional alterations in the peripartum period in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overlapping but distinct profiles of gene expression elicited by glucocorticoids and progestins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticotropin-releasing factor: long-lasting facilitation of the acoustic startle reflex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gender differences in depression and response to antidepressant treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of prenatal stress and gonadal hormone condition on depressive behaviors of female and male rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen and cognition: applying preclinical findings to clinical perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of estradiol on immediate early gene expression associated with ovulation in lactating rats: role of nutritional status.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sex differences in animal tests of anxiety.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sex-dependent effects of inescapable shock administration on shuttlebox-escape performance and elevated plus-maze behavior

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of corticotropin-releasing factor on central respiratory activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Medroxyprogesterone acetate: receptor binding and correlated effects on steroidogenesis in rat granulosa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticotropin-releasing factor potentiates acoustic startle in rats: blockade by chlordiazepoxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticotropin-releasing hormone increases tonic but not sensory-evoked activity of noradrenergic locus coeruleus neurons in unanesthetized rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional hemodynamic responses to central administration of corticotropin-releasing factor (CRF).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracisternal injection of CRF antagonist blocks surgical stress-induced inhibition of gastric secretion in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ontogeny of sex differences in estrogen-induced progesterone receptors in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Corticotropin-releasing factor disrupts sensory responses of brain noradrenergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the primary and secondary antifluoresceyl antibody response in rats by 17 beta-estradiol

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of progestins to the glucocorticoid receptor. Correlation to their glucocorticoid-like effects on in vitro functions of human mononuclear leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Background, development and properties of progestagens, with special reference to medroxyprogesterone acetate (MPA)

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alphaxalone, a steroid anesthetic, inhibits the startle-enhancing effects of corticotropin releasing factor, but not strychnine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of corticosterone on the enhancement of the acoustic startle reflex by corticotropin releasing factor (CRF).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of rat pup ultrasonic vocalizations by the neuroactive steroid allopregnanolone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of [3H]flunitrazepam binding by natural and synthetic progestational agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flumazenil blocks the anxiolytic action of allopregnanolone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the locus coeruleus in emotional activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding specificity of medroxyprogesterone acetate and proligestone for the progesterone and glucocorticoid receptor in the dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ovarian steroid regulation of estrogen and progesterone receptor messenger ribonucleic acid in the anteroventral periventricular nucleus of the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrasonic vocalizations in rat pups: modulation at the gamma-aminobutyric acidA receptor complex and the neurosteroid recognition site.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the hippocampus, the bed nucleus of the stria terminalis, and the amygdala in the excitatory effect of corticotropin-releasing hormone on the acoustic startle reflex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double dissociation between the involvement of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in startle increases produced by conditioned versus unconditioned fear.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Responses of plasma "estradiol" and plasma LH to ovariectomy, ovariectomy plus adrenalectomy, and estrogen injection at various ages

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testicular hormones do not regulate sexually dimorphic Pavlovian fear conditioning or perforant-path long-term potentiation in adult male rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of corticotropin-releasing factor in depression and anxiety disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progesterone receptor isoforms are differentially regulated by sex steroids in the rat forebrain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15537900

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1386-04.2004

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730196&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730196&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6730196&resulttype=core&format=json

12 May 2020

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