(Q45161628)

10 December 2017

Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis (English)

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10 December 2017

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1 reference

Marcela Brissova

1

1 reference

10 December 2017

Michael Blaha

2

1 reference

10 December 2017

Cathi Spear

3

1 reference

10 December 2017

Wendell Nicholson

4

1 reference

10 December 2017

Aramandla Radhika

5

1 reference

10 December 2017

Masakazu Shiota

6

1 reference

10 December 2017

Maureen J Charron

7

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10 December 2017

Christopher V E Wright

8

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10 December 2017

Alvin C Powers

9

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10 December 2017

23 November 2004

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American Journal of Physiology - Endocrinology and Metabolism

10 December 2017

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10 December 2017

288

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10 December 2017

E707-14

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10 December 2017

4

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beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

10 December 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Islet growth and development in the adult

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Pancreatic organogenesis--developmental mechanisms and implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Increased islet apoptosis in Pdx1+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Pdx1 restores beta cell function in Irs2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Pdx-1 enables insulin secretion by regulating synaptotagmin 1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

PDX-1 mediates glucose responsiveness of GAD(67), but not GAD(65), gene transcription in islets of Langerhans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

IRS proteins and the common path to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00252.2004

10.1152/AJPENDO.00252.2004

21 January 2018

Identifiers

DOI

1 reference

10 December 2017

1 reference