(Q45174150)

10 December 2017

title

Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice (English)

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10 December 2017

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Qihong Zhang

1

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10 December 2017

James R Davenport

2

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10 December 2017

Mandy J Croyle

3

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10 December 2017

Courtney J Haycraft

4

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10 December 2017

Bradley K Yoder

5

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10 December 2017

publication date

1 January 2005

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10 December 2017

published in

Laboratory Investigation

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10 December 2017

volume

85

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10 December 2017

issue

1

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10 December 2017

page(s)

45-64

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https://scigraph.springernature.com/pub.10.1038/labinvest.3700207

10 December 2017

exact match

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Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

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CHE-3, a cytosolic dynein heavy chain, is required for sensory cilia structure and function in Caenorhabditis elegans

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The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane

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The bld1 mutation identifies the Chlamydomonas osm-6 homolog as a gene required for flagellar assembly

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7 January 2021

An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons

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Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein

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Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II

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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

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The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

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Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

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Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome

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7 January 2021

Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene

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7 January 2021

Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport

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7 January 2021

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

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Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

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Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice.

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Anomalous development of the hepatobiliary system in the Inv mouse.

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7 January 2021

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7 January 2021

Abdominal sonographic study of autosomal dominant polycystic kidney disease

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7 January 2021

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7 January 2021

Autosomal recessive polycystic kidney disease

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7 January 2021

Intercellular signals regulating pancreas development and function

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Cardiac defects and renal failure in mice with targeted mutations in Pkd2

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Abnormal nodal flow precedes situs inversus in iv and inv mice

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7 January 2021

Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis

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7 January 2021

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7 January 2021

Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice

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7 January 2021

Hedgehog signalling in the mouse requires intraflagellar transport proteins

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7 January 2021

Combined activities of hedgehog signaling inhibitors regulate pancreas development

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Hedgehog signaling in pancreas development

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Sonic hedgehog is required early in pancreatic islet development

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Distribution of Indian hedgehog and its receptors patched and smoothened in human chronic pancreatitis

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Hedgehog signaling regulation of insulin production by pancreatic beta-cells

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organisms

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Somatic inactivation of Pkd2 results in polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Mist1 expression is a common link among serous exocrine cells exhibiting regulated exocytosis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Progressive disruption of acinar cell calcium signaling is an early feature of cerulein-induced pancreatitis in mice

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Early changes in pancreatic acinar cell calcium signaling after pancreatic duct obstruction

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Early trypsinogen activation in acute pancreatitis.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Ultrastructural responses of rat exocrine pancreas to cholecystokinin octapeptide and secretin

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Intramanchette transport (IMT): managing the making of the spermatid head, centrosome, and tail

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Intraflagellar Transport

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

The ultrastructure of primary cilia in the endocrine and excretory duct cells of the pancreas of mice and rats

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Murine autosomal recessive polycystic kidney disease with multiorgan involvement induced by the cpk gene

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Early development of polycystic kidney disease in transgenic mice expressing an activated mutant of the beta-catenin gene

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Overexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Aberrant CFTR-dependent HCO3- transport in mutations associated with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Regulatory interaction between the cystic fibrosis transmembrane conductance regulator and HCO3- salvage mechanisms in model systems and the mouse pancreatic duct

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Cystic fibrosis transmembrane conductance regulator regulates luminal Cl-/HCO3- exchange in mouse submandibular and pancreatic ducts

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Murine models of polycystic kidney disease: molecular and therapeutic insights

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Glycemic control in mice with targeted disruption of the glucagon receptor gene

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Hypoglycemia in diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Intra-islet insulin permits glucose to directly suppress pancreatic A cell function

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Intra-Islet Somatostatin Regulates Glucagon Release via Type 2 Somatostatin Receptors in Rats

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

Localization of glucokinase-like immunoreactivity in the rat lower brain stem: for possible location of brain glucose-sensing mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700207

7 January 2021

10.1038/LABINVEST.3700207

Identifiers

DOI

1 reference

Dimensions Publication ID

10 December 2017

1002840799

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1 reference