(Q45177699)

10 December 2017

title

Janus kinase 3: a novel target for selective transplant immunosupression (English)

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10 December 2017

Hemangshu Podder

1

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10 December 2017

Barry D Kahan

series ordinal

2

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10 December 2017

language of work or name

English

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publication date

1 December 2004

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Expert Opinion on Therapeutic Targets

10 December 2017

published in

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10 December 2017

volume

8

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10 December 2017

issue

6

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10 December 2017

page(s)

613-629

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Cyclosporin A in patients receiving renal allografts from cadaver donors

10 December 2017

cites work

1 reference

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Immunosuppression minimization: current and future trends in transplant immunosuppression

21 January 2018

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Complete genomic organization and promoter analysis of the round-spotted pufferfish JAK1, JAK2, JAK3, and TYK2 genes

21 January 2018

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Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation

21 January 2018

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Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

21 January 2018

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The JAK/STAT pathway and Drosophila development

21 January 2018

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Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice

21 January 2018

1 reference

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Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain

21 January 2018

1 reference

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Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

21 January 2018

1 reference

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Peripheral expression of Jak3 is required to maintain T lymphocyte function

21 January 2018

1 reference

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Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

21 January 2018

1 reference

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Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

21 January 2018

1 reference

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Critical sites for the interaction between IL-2Rgamma and JAK3 and the following signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

STATs and gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Requirement of serine phosphorylation for formation of STAT-promoter complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells

21 January 2018

1 reference

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Crucial role of Jak3 in negative selection of self-reactive T cells.

21 January 2018

1 reference

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Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development

21 January 2018

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T cell death and transplantation tolerance.

21 January 2018

1 reference

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Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin

21 January 2018

1 reference

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Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice

21 January 2018

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Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation

21 January 2018

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Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

21 January 2018

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F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Naphthyl ketones: a new class of Janus kinase 3 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Use of leflunomide in human renal transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

The novel JAK-3 inhibitor CP-690550 is a potent immunosuppressive agent in various murine models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

First report of cryopreserved human hepatocytes based bioartificial liver successfully used as a bridge to liver transplantation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Median effect analysis of efficacy versus adverse effects of immunosuppressants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

Molecular Modeling of the Jak3 Kinase Domains and Structural Basis for Severe Combined Immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.6.613

21 January 2018

Identifiers

DOI

10.1517/14728222.8.6.613

1 reference

10 December 2017

1 reference