(Q45184208)

10 December 2017

title

Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program (English)

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10 December 2017

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5

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10 December 2017

author name string

Sashidhar S Nakerakanti

1

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10 December 2017

Bagrat Kapanadze

2

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10 December 2017

Masaomi Yamasaki

3

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10 December 2017

Margaret Markiewicz

4

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10 December 2017

language of work or name

English

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publication date

6 July 2006

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Journal of Biological Chemistry

10 December 2017

published in

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10 December 2017

volume

281

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10 December 2017

issue

35

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10 December 2017

page(s)

25259-25269

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Molecular biology of the Ets family of transcription factors

10 December 2017

cites work

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The Ets family contains transcriptional activators and repressors involved in angiogenesis.

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Ets factors and regulation of the extracellular matrix

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Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

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Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment

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Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region

21 January 2018

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Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta

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Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice

21 January 2018

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Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor

21 January 2018

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Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia

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Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter

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The CCN family: a new stimulus package

21 January 2018

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Structural and functional properties of CCN proteins

21 January 2018

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Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts

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Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.

21 January 2018

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Angiotensin II induces connective tissue growth factor gene expression via calcineurin-dependent pathways

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Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.

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A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis

21 January 2018

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Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.

21 January 2018

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Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets

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Differential involvement of the integrin-linked kinase (ILK) in RhoA-dependent rearrangement of F-actin fibers and induction of connective tissue growth factor (CTGF).

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Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium

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Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin

21 January 2018

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Coexamination of site-specific transcription factor binding and promoter activity in living cells

21 January 2018

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Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

21 January 2018

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Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?

21 January 2018

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Differential regulation of interstitial collagenase (MMP-1) gene expression by ETS transcription factors

21 January 2018

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Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors

21 January 2018

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An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation

21 January 2018

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Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1

21 January 2018

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Transforming growth factor beta enhances the glucocorticoid response of the mouse mammary tumor virus promoter through Smad and GA-binding proteins

21 January 2018

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Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.

21 January 2018

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Ets target genes: past, present and future

21 January 2018

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Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M600466200

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10 December 2017

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