(Q45205491)

10 December 2017

title

Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice (English)

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10 December 2017

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10 December 2017

Y Kagawa

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10 December 2017

publication date

29 December 2004

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10 December 2017

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10 December 2017

volume

48

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10 December 2017

issue

1

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10 December 2017

page(s)

58-67

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Islet growth and development in the adult

10 December 2017

cites work

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12 December 2020

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

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12 December 2020

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication

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12 December 2020

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

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12 December 2020

Accelerated loss of islet beta cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus

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12 December 2020

Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery

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12 December 2020

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

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12 December 2020

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

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12 December 2020

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

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12 December 2020

Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction

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12 December 2020

Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.

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12 December 2020

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

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12 December 2020

Biotin enhances ATP synthesis in pancreatic islets of the rat, resulting in reinforcement of glucose-induced insulin secretion

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12 December 2020

Influences of inbreeding and genetics on telomere length in mice

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12 December 2020

Genetic analysis of ageing: role of oxidative damage and environmental stresses.

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12 December 2020

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

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12 December 2020

Replicative senescence of human fibroblasts: the role of Ras-dependent signaling and oxidative stress

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12 December 2020

Regulation of proinsulin synthesis in pancreatic islets and a new aspect to insulin-dependent diabetes

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12 December 2020

Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity

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12 December 2020

Detection of live Trypanosoma cruzi in tissues of infected mice by using histochemical stain for beta-galactosidase

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12 December 2020

Diet-induced type II diabetes in C57BL/6J mice

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12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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12 December 2020

Beta-cell ontogeny: growth and death

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12 December 2020

The serial cultivation of human diploid cell strains

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12 December 2020

Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction

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12 December 2020

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

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12 December 2020

Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

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12 December 2020

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression

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12 December 2020

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

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12 December 2020

Hypervariable ultra-long telomeres in mice

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12 December 2020

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

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12 December 2020

Influence of aging and calorie restriction on MAPKs activity in rat kidney

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12 December 2020

Glucotoxicity and beta-cell failure in type 2 diabetes mellitus

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12 December 2020

Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

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12 December 2020

Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

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12 December 2020

AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet

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12 December 2020

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

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12 December 2020

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

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12 December 2020

Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice

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12 December 2020

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

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12 December 2020

Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro

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12 December 2020

10.1007/S00125-004-1605-2

Identifiers

DOI

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Dimensions Publication ID

10 December 2017

1047007729

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