(Q45209344)

10 December 2017

title

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia (English)

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10 December 2017

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D J P M Stumpel

1

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10 December 2017

P Schneider

2

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10 December 2017

L Seslija

3

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10 December 2017

H Osaki

4

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10 December 2017

O Williams

5

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10 December 2017

R Pieters

6

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10 December 2017

R W Stam

7

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10 December 2017

publication date

21 October 2011

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10 December 2017

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10 December 2017

volume

26

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10 December 2017

issue

4

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10 December 2017

page(s)

682-692

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https://scigraph.springernature.com/pub.10.1038/leu.2011.278

10 December 2017

exact match

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cites work

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Acute lymphoblastic leukaemia

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Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots

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The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

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Definitive hematopoiesis requires the mixed-lineage leukemia gene

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Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis

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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

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The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

21 January 2018

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Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options

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Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

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Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia

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D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid acute lymphoblastic leukemia.

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MLL targets SET domain methyltransferase activity to Hox gene promoters

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The RUNX genes: gain or loss of function in cancer

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The GTPase Ran: regulation of cell life and potential roles in cell transformation.

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DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

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MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

21 January 2018

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Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

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21 January 2018

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21 January 2018

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A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2011.278

MLL-aberrant leukemia: complete cytogenetic remission following treatment with a histone deacetylase inhibitor (HDACi)

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2011.278

Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2011.278

Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.278

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/LEU.2011.278

1 reference

Dimensions Publication ID

10 December 2017

1045480274

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1 reference