(Q45235059)

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Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level coexpression of heat shock protein 70.

scientific article published in June 2005

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Europe PubMed Central

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7 January 2020

Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level coexpression of heat shock protein 70 (English)

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Europe PubMed Central

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7 January 2020

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Stephen M Todryk

2

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7 January 2020

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Hakim A Djeha

1

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7 January 2020

Steven Pelech

3

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7 January 2020

Christopher J Wrighton

4

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7 January 2020

Alistair S Irvine

5

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7 January 2020

Andrew Mountain

6

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7 January 2020

Kai S Lipinski

7

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7 January 2020

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1 June 2005

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7 January 2020

Cancer Gene Therapy

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Europe PubMed Central

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7 January 2020

12

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7 January 2020

6

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7 January 2020

560-571

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7 January 2020

Approaches to gene-directed enzyme prodrug therapy (GDEPT).

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The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.

1 reference

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The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite

1 reference

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21 January 2018

Nitroreductase-mediated cell ablation is very rapid and mediated by a p53-independent apoptotic pathway

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21 January 2018

Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors

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Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer

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Gene-based strategies for the immunotherapy of cancer

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Prostate tumor microenvironment alters immune cells and prevents long-term survival in an orthotopic mouse model following flt3-ligand/CD40-ligand immunotherapy

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Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer.

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Facets of heat shock protein 70 show immunotherapeutic potential.

1 reference

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CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin

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21 January 2018

CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexes

1 reference

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21 January 2018

Roles of heat-shock proteins in innate and adaptive immunity

1 reference

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21 January 2018

Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.

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21 January 2018

Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway

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21 January 2018

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

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21 January 2018

Natural adjuvants: endogenous activators of dendritic cells

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Immune enhancement of nitroreductase-induced cytotoxicity: studies using a bicistronic adenovirus vector

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21 January 2018

Tumour-specific therapeutic adenovirus vectors: repression of transgene expression in healthy cells by endogenous p53.

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21 January 2018

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

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Limited efficacy of the HSV-TK/GCV system for gene therapy of malignant gliomas and perspectives for the combined transduction of the interleukin-4 gene

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21 January 2018

Local and systemic antitumor response after combined therapy of mouse metastatic tumors with tumor cells expressing IFN-alpha and HSVtk: perspectives for the generation of cancer vaccines

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21 January 2018

Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6 or B7-1.

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Combined suicide and granulocyte-macrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity

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Combination suicide/cytokine gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine.

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Adenovirus-mediated GM-CSF gene and cytosine deaminase gene transfer followed by 5-fluorocytosine administration elicit more potent antitumor response in tumor-bearing mice

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Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil

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Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954

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7 January 2021

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LIGHTing the way for tumor immunity

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A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides

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HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

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Efficient nonviral transfection of dendritic cells and their use for in vivo immunization

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Induction of systemic antitumor immunity by gene transfer of mammalian heat shock protein 70.1 into tumors in situ

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10.1038/SJ.CGT.7700807

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15665820%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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24 November 2022

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7 January 2020

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