(Q45252238)

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Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects.

scientific article published on 25 August 2010

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scholarly article

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11 February 2020

Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects (English)

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11 February 2020

Cytomegalovirus

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4

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11 February 2020

Derek C Macallan

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11 February 2020

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11 February 2020

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11 February 2020

author name string

Diana L Wallace

1

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11 February 2020

Joanne E Masters

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11 February 2020

Catherine M De Lara

3

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11 February 2020

Andrew Worth

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11 February 2020

Yan Zhang

6

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11 February 2020

Shikha R Kumar

7

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11 February 2020

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25 August 2010

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11 February 2020

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11 February 2020

132

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11 February 2020

1

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11 February 2020

27-38

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11 February 2020

Cytomegalovirus infection reduces telomere length of the circulating T cell pool.

1 reference

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Senescence of the human immune system

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Measurement of proliferation and disappearance of rapid turnover cell populations in human studies using deuterium-labeled glucose.

1 reference

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The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo

1 reference

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Phenotype and function of human T lymphocyte subsets: consensus and issues

1 reference

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27 August 2018

Dynamics of T cell memory in human cytomegalovirus infection

1 reference

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CD95-mediated apoptosis in naïve, central and effector memory subsets of CD4+ and CD8+ T cells in aged humans

1 reference

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Measurement of cell proliferation by heavy water labeling.

1 reference

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27 August 2018

Differential costimulation through CD137 (4-1BB) restores proliferation of human virus-specific "effector memory" (CD28(-) CD45RA(HI)) CD8(+) T cells

1 reference

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Chronic herpesvirus reactivation occurs in aging

1 reference

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27 August 2018

CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015072

27 August 2018

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015072

27 August 2018

Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion.

1 reference

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T cells and viral persistence: lessons from diverse infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015072

27 August 2018

Memory T cell homeostasis and senescence during aging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015072

27 August 2018

Measuring lymphocyte kinetics in tropical field settings

1 reference

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27 August 2018

Human immunosenescence: is it infectious?

1 reference

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27 August 2018

Non-malignant clonal expansions of CD8+ memory T cells in aged individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015072

27 August 2018

Herpesvirus-specific CD8 T cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015072

27 August 2018

Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015072

27 August 2018

Will telomere erosion lead to a loss of T-cell memory?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015072

27 August 2018

Direct measurement of T cell subset kinetics in vivo in elderly men and women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015072

27 August 2018

Measurement and modeling of human T cell kinetics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3015072

27 August 2018

Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV.

1 reference

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Lymphocyte kinetics: the interpretation of labelling data

1 reference

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Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals.

1 reference

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Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

1 reference

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Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study

1 reference

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Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors.

1 reference

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Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57+ CD28- CD8+ T-cell population

1 reference

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Evidence that human CD8+CD45RA+CD27- cells are induced by antigen and evolve through extensive rounds of division.

1 reference

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1 reference

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Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance

1 reference

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Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells

1 reference

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Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study

1 reference

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inferred from PubMed ID database lookup

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1 reference

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1 reference

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inferred from PubMed ID database lookup

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2567.2010.03334.X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20738423%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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Europe PubMed Central

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11 February 2020

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