(Q45270557)

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The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats.

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scholarly article

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717208%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717208%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717208%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

author name string

Jason P Schroeder

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717208%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

David H Overstreet

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717208%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

publication date

17 February 2005

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717208%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

number of pages

9

1 reference

based on heuristic

inferred from page(s)

Psychopharmacology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717208%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

179

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717208%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717208%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

262-270

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717208%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

https://scigraph.springernature.com/pub.10.1007/s00213-005-2175-9

0 references

Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-2175-9

21 January 2018

Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: the involvement of the nucleus accumbens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of an alcohol-deprivation effect in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rodent lines selected for factors affecting alcohol consumption

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ventral tegmental microinjections of quinpirole decrease ethanol and sucrose-reinforced responding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor agonists alter neuronal excitability and Ca2+ levels via the phospholipase C transduction pathway in cultured Purkinje neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of polyamines and NMDA receptors in ethanol dependence and withdrawal.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic ethanol treatment and withdrawal alter ACPD-evoked calcium signals in developing Purkinje neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug addiction, dysregulation of reward, and allostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ionotropic glutamate receptors as sites of action for ethanol in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol, sedative hypnotics, and glutamate receptor function in brain and cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant access conditions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of intraaccumbens injections of dopamine agonists and antagonists on sucrose and sucrose-ethanol reinforced responding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent animal models of alcoholism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ventral tegmental microinjections of the GABAA agonist muscimol on self-administration of ethanol and sucrose.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced stress-induced hyperthermia in mGluR5 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mGlu5 receptor antagonists: a novel class of anxiolytics?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol action on excitatory amino acid activated ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-stimulation of mGluR5 and N-Methyl-D-aspartate Receptors Is Required for Potentiation of Excitatory Synaptic Transmission in Hippocampal Neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic ethanol on mRNA levels of IP3R1, IP3 3-kinase and mGluR1 in mouse Purkinje neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Group I metabotropic glutamate receptors: implications for brain diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aspartate and glutamate transport in acutely and chronically ethanol exposed neonatal rat primary astrocyte cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ethanol on stimulated inositol phospholipid hydrolysis in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long and short alcohol deprivation: effects on AA and P alcohol-preferring rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of the effects of prenatal or early postnatal ethanol exposure on brain ligand-gated ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alcohol exposure during brain development reduces 3H-MK-801 binding and enhances metabotropic-glutamate receptor-stimulated phosphoinositide hydrolysis in rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alcohol self-administration: further examination of the role of dopamine receptors in the nucleus accumbens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabotropic glutamate receptors: structure and functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute ethanol alters calcium signals elicited by glutamate receptor agonists and K+ depolarization in cultured cerebellar Purkinje neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of repeated alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute effects of ethanol on GABAA and glycine receptor function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGlu5 receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A2A receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prenatal ethanol exposure enhances glutamate release stimulated by quisqualate in rat cerebellar granule cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Second messenger pathways involved in up-regulation of an L-type calcium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate-mediated transmission, alcohol, and alcoholism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naltrexone in the treatment of alcohol dependence

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel uncompetitive N-methyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/15717208

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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