(Q45306884)

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Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 December 2017

Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

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author name string

Joana Branco

1

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Ismael Al-Ramahi

2

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Lubna Ukani

3

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

Alma M Pérez

4

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Europe PubMed Central

PubMed publication ID

11 December 2017

Pedro Fernandez-Funez

5

1 reference

Europe PubMed Central

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11 December 2017

Diego Rincón-Limas

6

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Europe PubMed Central

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11 December 2017

Juan Botas

7

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Europe PubMed Central

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11 December 2017

publication date

5 November 2007

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Europe PubMed Central

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11 December 2017

Human Molecular Genetics

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11 December 2017

17

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Europe PubMed Central

PubMed publication ID

11 December 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

376-390

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Europe PubMed Central

PubMed publication ID

11 December 2017

Trinucleotide Repeat Disorders

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Mouse and fly models of neurodegeneration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Diseases of unstable repeat expansion: mechanisms and common principles

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Normal huntingtin function: an alternative approach to Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

The pathogenesis of spinocerebellar ataxia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Beyond the Qs in the polyglutamine diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Polyglutamine neurodegenerative diseases and regulation of transcription: assembling the puzzle

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

The role of RNA and RNA processing in neurodegeneration.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Synaptic dysfunction in Huntington's disease: a new perspective.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Deranged neuronal calcium signaling and Huntington disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Homophila: human disease gene cognates in Drosophila

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Identification of genes that modify ataxin-1-induced neurodegeneration.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Current thoughts on the phosphatidylinositol transfer protein family

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

The Drosophila phosphatidylinositol transfer protein encoded by vibrator is essential to maintain cleavage-furrow ingression in cytokinesis.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Unfolding the role of protein misfolding in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Transcriptional abnormalities in Huntington disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Pathogenic RNA repeats: an expanding role in genetic disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

A neurotoxic peripherin splice variant in a mouse model of ALS

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

The molecular bases of spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

The spinocerebellar ataxia type 1 protein, ataxin-1, has RNA-binding activity that is inversely affected by the length of its polyglutamine tract

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

GAPs in growth factor signalling

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Rho GTPases regulate axon growth through convergent and divergent signaling pathways.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Does isoform diversity explain functional differences in the 14-3-3 protein family?

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Biological functions of phosphatidylinositol transfer proteins

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Abnormal activity of membrane phospholipid synthetic enzymes in the brain of patients with Friedreich's ataxia and spinocerebellar atrophy type-1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Biochemical aspects of neurodegeneration in human brain: involvement of neural membrane phospholipids and phospholipases A2.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Regulation of intracellular HAP1 trafficking

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Hypothesis: Huntingtin may function in membrane association and vesicular trafficking

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Huntingtin associates with acidic phospholipids at the plasma membrane

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

pasilla, the Drosophila homologue of the human Nova-1 and Nova-2 proteins, is required for normal secretion in the salivary gland

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM315

21 January 2018

Identifiers

10.1093/HMG/DDM315

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

ResearchGate publication ID

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