(Q45314265)

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Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5358565)

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8 July 2022

1 reference

8 July 2022

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-5358565

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8 July 2022

MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop

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8 July 2022

MSH2:MSH6 exchanges ADP for ATP

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8 July 2022

Formation of MSH2:MSH6 Complex

1 reference

8 July 2022

Formation of MSH1:PMS2 Complex

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8 July 2022

MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA

1 reference

8 July 2022

MLH1:PMS2 makes single strand incision near 1-2 base mismatch

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8 July 2022

EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)

1 reference

8 July 2022

EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch

1 reference

8 July 2022

DNA polymerase delta polymerizes DNA across single stranded gap

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8 July 2022

DNA ligase I ligates single stranded nick in double stranded DNA

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8 July 2022

Mismatch repair deficiency associated with overexpression of the MSH3 gene

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8 July 2022

Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities

1 reference

8 July 2022

DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q45314265)

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

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