(Q45316775)

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TP53 Regulates Transcription of Caspase Activators and Caspases

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6803207)

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8 July 2022

TP53 Regulates Transcription of Cell Death Genes

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-6803207

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TP53 stimulates APAF1 gene expression

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TP53 binds the APAF1 gene promoter

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TP53 binds the PIDD1 gene

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TP53 stimulates PIDD1 expression

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ATM phosphorylates PIDD1

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PIDD1 translocates to the cytosol

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PIDD1 associates with CRADD

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The PIDDosome activates CASP2

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The PIDDosome binds CASP2

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TP53 binds the NLRC4 gene

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TP53 stimulates NLRC4 expression

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TP53 family members bind the CASP1 gene

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TP53 family members stimulate CASP1 expression

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TP53 stimulates CASP6 expression

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TP53 binds the CASP6 gene

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TP53 binds the CASP10 gene

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TP53 stimulates CASP10 expression

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Caspase 10 levels are increased following DNA damage in a p53-dependent manner

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Apoptotic threshold is lowered by p53 transactivation of caspase-6

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Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

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APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis

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Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

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Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

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8 July 2022

Direct transcriptional activation of human caspase-1 by tumor suppressor p53.

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45316775)

TP53 Regulates Transcription of Caspase Activators and Caspases

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