(Q45316772)

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TP53 Regulates Transcription of Cell Death Genes

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5633008)

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8 July 2022

regulation of apoptotic process

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8 July 2022

Transcriptional Regulation by TP53

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8 July 2022

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https://identifiers.org/reactome:R-HSA-5633008

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TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

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TP53 Regulates Transcription of Death Receptors and Ligands

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TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

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TP53 Regulates Transcription of Caspase Activators and Caspases

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The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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Caspase 10 levels are increased following DNA damage in a p53-dependent manner

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Transcriptional control of human p53-regulated genes

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Apoptotic threshold is lowered by p53 transactivation of caspase-6

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Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

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A complex barcode underlies the heterogeneous response of p53 to stress

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NDRG1 is necessary for p53-dependent apoptosis

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site.

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Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin

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8 July 2022

Bcl-G, a novel pro-apoptotic member of the Bcl-2 family

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8 July 2022

ASPP1 and ASPP2: common activators of p53 family members

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p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway

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Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer

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p53 upregulates death receptor 4 expression through an intronic p53 binding site

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Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.

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DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

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BID regulation by p53 contributes to chemosensitivity

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Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53

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Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

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p53 in survival, death and metabolic health: a lifeguard with a licence to kill

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Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity

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PUMA, a novel proapoptotic gene, is induced by p53

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Induction of the growth inhibitor IGF-binding protein 3 by p53

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Identification of novel p53 target genes in ionizing radiation response.

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p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion

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Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site.

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p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

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APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis

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Perp is a mediator of p53-dependent apoptosis in diverse cell types

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Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

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A polymorphic microsatellite that mediates induction of PIG3 by p53.

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TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

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BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma

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iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes

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Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family

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ASPP proteins specifically stimulate the apoptotic function of p53

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PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family

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8 July 2022

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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8 July 2022

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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8 July 2022

AMID is a p53-inducible gene downregulated in tumors

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8 July 2022

ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo

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8 July 2022

Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene

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Bcl-2 family member Bcl-G is not a proapoptotic protein.

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Caspase-1 is a novel target of p63 in tumor suppression

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Unravelling mechanisms of p53-mediated tumour suppression

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Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

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Direct transcriptional activation of human caspase-1 by tumor suppressor p53.

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Perp is a p63-regulated gene essential for epithelial integrity.

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BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma.

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P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma

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8 July 2022

Identifiers

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8 July 2022

(Q45316772)

TP53 Regulates Transcription of Cell Death Genes

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