(Q24299608)

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

Naoe Taira

1

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Keishi Nihira

2

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Tomoko Yamaguchi

3

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Yoshio Miki

4

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Kiyotsugu Yoshida

SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins

5

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language of work or name

English

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publication date

9 March 2007

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published in

Molecular Cell

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volume

25

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page(s)

725-38

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issue

5

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cites work

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The p53 response to DNA damage

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Differing substrate specificities of members of the DYRK family of arginine-directed protein kinases

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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p53, the cellular gatekeeper for growth and division

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ATM and ATR: networking cellular responses to DNA damage

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p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

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DNA mismatch repair and cancer

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Oxidants, oxidative stress and the biology of ageing

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The DNA damage response: putting checkpoints in perspective

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JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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Determination of the specific substrate sequence motifs of protein kinase C isozymes

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ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

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Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9

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c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage

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Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage

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