(Q41759568)

8 October 2017

A transactivation-deficient mouse model provides insights into Trp53 regulation and function (English)

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8 October 2017

G S Jimenez

1

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8 October 2017

M Nister

2

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8 October 2017

J M Stommel

3

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8 October 2017

M Beeche

4

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8 October 2017

E A Barcarse

5

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8 October 2017

X Q Zhang

6

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8 October 2017

S O'Gorman

7

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8 October 2017

G M Wahl

8

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8 October 2017

language of work or name

English

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publication date

1 September 2000

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8 October 2017

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8 October 2017

26

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8 October 2017

37-43

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8 October 2017

1

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8 October 2017

p53: puzzle and paradigm

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7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

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7 January 2021

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

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7 January 2021

Essential role for p53-mediated transcription in E1A-induced apoptosis

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7 January 2021

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

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7 January 2021

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

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7 January 2021

p53 Protein exhibits 3'-to-5' exonuclease activity

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7 January 2021

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

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7 January 2021

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

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7 January 2021

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

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7 January 2021

A subset of p53-deficient embryos exhibit exencephaly

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7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

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7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

Mdm2 promotes the rapid degradation of p53

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7 January 2021

How p53 binds DNA as a tetramer

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7 January 2021

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes

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7 January 2021

Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation

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7 January 2021

Molecular characterization of the hdm2-p53 interaction

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7 January 2021

Inhibition of RNA polymerase II as a trigger for the p53 response

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7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

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7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

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7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

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7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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7 January 2021

Tumor surveillance via the ARF-p53 pathway.

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7 January 2021

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

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7 January 2021

Oncogenic forms of p53 inhibit p53-regulated gene expression

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7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

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7 January 2021

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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7 January 2021

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

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7 January 2021

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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7 January 2021

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

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7 January 2021

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

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7 January 2021

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

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7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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7 January 2021

Identifiers

DOI

10.1038/79152

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Dimensions Publication ID

8 October 2017

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