(Q53461564)

14 May 2018

title

Induction of apoptosis in HeLa cells by trans-activation-deficient p53 (English)

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

transcriptional activation

23 July 2024

main subject

apoptotic process

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7657168

23 July 2024

author name string

Y. Haupt

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7657168

23 July 2024

S. Rowan

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7657168

23 July 2024

E. Shaulian

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7657168

23 July 2024

K. H. Vousden

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7657168

23 July 2024

M. Oren

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7657168

23 July 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=7657168

23 July 2024

publication date

1 September 1995

1 reference

14 May 2018

published in

Genes & Development

1 reference

14 May 2018

volume

9

1 reference

14 May 2018

issue

17

1 reference

14 May 2018

page(s)

2170-2183

1 reference

14 May 2018

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.7973727

Suppression of human colorectal carcinoma cell growth by wild-type p53

1

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

23 July 2024

2

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Cancer genetics. Is p53 the only real tumor suppressor gene?

23 July 2024

3

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

23 July 2024

4

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Growth factor modulation of p53-mediated growth arrest versus apoptosis

23 July 2024

5

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Bcl-2 blocks p53-dependent apoptosis

23 July 2024

7

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras.

23 July 2024

9

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

23 July 2024

10

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Features of apoptotic cells measured by flow cytometry

23 July 2024

11

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

23 July 2024

12

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

23 July 2024

13

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

The tumor suppressor p53.

23 July 2024

14

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

23 July 2024

15

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

WAF1, a potential mediator of p53 tumor suppression

23 July 2024

17

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Wild-type p53 can inhibit oncogene-mediated focus formation

23 July 2024

20

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

The p53 proto-oncogene can act as a suppressor of transformation

23 July 2024

21

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53: a glimpse at the puppet behind the shadow play

23 July 2024

22

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

23 July 2024

23

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Wild-type p53 can down-modulate the activity of various promoters

23 July 2024

24

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

23 July 2024

26

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Biochemical properties and biological effects of p53.

23 July 2024

27

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Down-regulation of bcl-2 by p53 in breast cancer cells.

23 July 2024

29

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Different tumor-derived p53 mutants exhibit distinct biological activities

23 July 2024

30

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

23 July 2024

31

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Clinical implications of the p53 tumor-suppressor gene

23 July 2024

32

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Mediation of c-Myc-induced apoptosis by p53.

23 July 2024

34

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Cells expressing HPV16 E7 continue cell cycle progression following DNA damage induced p53 activation.

23 July 2024

35

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53

23 July 2024

37

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

23 July 2024

42

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

23 July 2024

43

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Identification of p53 as a sequence-specific DNA-binding protein

23 July 2024

44

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Regulation of fibronectin receptor distribution

23 July 2024

45

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

The tumor suppressor genes

23 July 2024

46

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

23 July 2024

47

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

23 July 2024

49

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

23 July 2024

50

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

23 July 2024

51

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function.

23 July 2024

52

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

23 July 2024

53

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

23 July 2024

54

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

23 July 2024

56

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

23 July 2024

58

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53: the ultimate tumor suppressor gene?

23 July 2024

59

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

23 July 2024

61

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

23 July 2024

62

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

23 July 2024

63

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Sequence-specific transcriptional activation is essential for growth suppression by p53.

23 July 2024

64

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

23 July 2024

65

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

How loops, beta sheets, and alpha helices help us to understand p53.

23 July 2024

66

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

23 July 2024

67

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

23 July 2024

71

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product

23 July 2024

72

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.

23 July 2024

75

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Transcriptional repression by the C-terminal domain of p53.

23 July 2024

76

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

23 July 2024

78

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein

23 July 2024

79

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

23 July 2024

80

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Inhibition of viral and cellular promoters by human wild-type p53

23 July 2024

84

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53-dependent apoptosis suppresses tumor growth and progression in vivo

23 July 2024

85

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

23 July 2024

86

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer

23 July 2024

87

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53 function and dysfunction

23 July 2024

88

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

23 July 2024

89

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

23 July 2024

90

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.

23 July 2024

91

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

23 July 2024

92

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

p53 and E2F-1 cooperate to mediate apoptosis

23 July 2024

93

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

The p53-mdm-2 autoregulatory feedback loop

23 July 2024

94

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

23 July 2024

96

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

A temperature-sensitive mutant of human p53.

23 July 2024

101

1 reference

https://api.crossref.org/works/10.1101/GAD.9.17.2170

23 July 2024

Identifiers

1 reference

14 May 2018

1 reference

14 May 2018