(Q45316789)

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Regulation of TP53 Activity through Association with Co-factors

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6804759)

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8 July 2022

regulation of signal transduction by p53 class mediator

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8 July 2022

Regulation of TP53 Activity

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8 July 2022

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https://identifiers.org/reactome:R-HSA-6804759

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TP53 binds ZNF385A gene

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TP53 stimulates ZNF385A transcription

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TP53 family members bind PPP1R13B or TP53BP2

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PHF20 binds TP53 dimethylated on K370 and K382

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AKT phosphorylates PHF20

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p-S291-PHF20 translocates to cytosol

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hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes

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Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

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A complex barcode underlies the heterogeneous response of p53 to stress

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Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults

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ASPP1 and ASPP2: common activators of p53 family members

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p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor

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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

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Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

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PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53

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A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response

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Transcriptional regulation by p53.

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Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53

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Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate.

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ASPP proteins specifically stimulate the apoptotic function of p53

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Mechanisms of regulatory diversity within the p53 transcriptional network

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Noncoding RNAs: The Missing “Linc” in p53-Mediated Repression

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Identifiers

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8 July 2022

(Q45316789)

Regulation of TP53 Activity through Association with Co-factors

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