(Q50290372)

English

TP53 binds POU4F1

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-6804402)

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Statements

biological process

1 reference

8 July 2022

Regulation of TP53 Activity through Association with Co-factors

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-6804402

1 reference

8 July 2022

p-S15,S20-TP53 Tetramer [nucleoplasm]

1

object has role

1 reference

8 July 2022

POU class 4 homeobox 1

1

object has role

1 reference

8 July 2022

p-S15,S20-TP53 Tetramer:POU4F1 [nucleoplasm]

1

object has role

1 reference

8 July 2022

p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor

1 reference

8 July 2022

Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate.

1 reference

8 July 2022

The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1).

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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