(Q45316840)

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Transcriptional Regulation by E2F6

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8953750)

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8 July 2022

negative regulation of G0 to G1 transition

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Generic Transcription Pathway

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https://identifiers.org/reactome:R-HSA-8953750

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RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6

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E2F6:TFDP1 binds to MGA:MAX

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EHMT1:EHMT2 complex binds E2F6.com-1 core

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CBX3 and PRC1.6 associate with E2F6.com-1

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E2F6.com-1 complex binds the E2F1 gene promoter

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E2F6:TFDP1/2 binds the E2F1 gene promoter

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E2F1 gene transcription is inhibited by E2F6

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E2F6 binds the PRC1 complex

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E2F6:TFDP1 binds EPC1

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E2F6:TFDP1:EPC1 binds the PRC2 complex

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E2F6 forms the PRC1L4 complex

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CDC7 gene expression is repressed by the PRC1L4 complex

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The PRC1L4 complex binds the CDC7 gene promoter

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The PRC1L4 complex binds the UXT gene promoter

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UXT gene expression is repressed by the PRC1L4 complex

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E2F1 binds APAF1 gene promoter

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E2F6 binds APAF1 gene promoter

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APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6

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CHEK1 phosphorylates E2F6

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E2F6 binds RAD51 gene promoter

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E2F1 binds RAD51 gene promoter

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RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6

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E2F6 binds RRM2 gene promoter

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E2F6 binds BRCA1 gene promoter

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BRCA1 gene expression is inhibited by E2F6

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E2F6 binds RBBP8 gene promoter

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RBBP8 gene expression is inhibited by E2F6

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E2F6 binds RBBP4 gene promoter

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RBBP4 gene expression is inhibited by E2F6

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E2F6 binds CBX5 gene promoter

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CBX5 gene expression is inhibited by E2F6

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E2F-6, a member of the E2F family that can behave as a transcriptional repressor

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8 July 2022

Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6

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E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription

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Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage.

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A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription

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A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

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Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6.

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L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

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E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9.

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Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription

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8 July 2022

Identifiers

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8 July 2022

(Q45316840)

Transcriptional Regulation by E2F6

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