(Q45316927)

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Common Pathway of Fibrin Clot Formation

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-140875)

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8 July 2022

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Formation of Fibrin Clot (Clotting Cascade)

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https://identifiers.org/reactome:R-HSA-140875

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prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)

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factor V -> factor Va + factor V activation peptide

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prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)

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factor Va + factor Xa -> Va:Xa complex (prothrombinase)

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fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B

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n fibrin monomers -> fibrin multimer

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factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides

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factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain

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fibrin multimer -> fibrin multimer, crosslinked + NH4+

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SERPINC1 binds SERPINC1 activators

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activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin

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thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin

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thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators

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activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin

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PROCR binds Protein C

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Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C

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Activated protein C is released from PROCR

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Activated protein C binds Protein S

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Activated protein C cleaves factor Va to factor Vi intermediate form

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Activated protein C cleaves Factor Va intermediate form for Factor Va

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Activated protein C cleaves factor VIIIa

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Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa)

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Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin.

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SERPINA5 binds activated protein C

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Activated protein C:PROCR binds F2R

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Soluble PROCR binds activated protein C

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Soluble PROCR binds PRTN3:CD177

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Factor Xa inhibitors binds Xa

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Factor Xa inhibitors bind Va:Xa

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The coagulation cascade: initiation, maintenance, and regulation

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8 July 2022

Identifiers

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8 July 2022

(Q45316927)

Common Pathway of Fibrin Clot Formation

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