(Q45316946)

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CD28 dependent PI3K/Akt signaling

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-389357)

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8 July 2022

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8 July 2022

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https://identifiers.org/reactome:R-HSA-389357

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8 July 2022

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CD28 bound PI3K phosphorylates PIP2 to PIP3

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8 July 2022

PIP3 recruits PDPK1 to the membrane

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8 July 2022

PIP3 recruits AKT to the membrane

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8 July 2022

PDPK1 phosphorylates AKT at T308

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8 July 2022

TORC2 (mTOR) phosphorylates AKT at S473

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8 July 2022

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8 July 2022

AKT interacts and phosphorylates Cot

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8 July 2022

p-S400-Cot phosphorylates NIK

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8 July 2022

Phosphoinositide 3-kinase in T cell activation and survival.

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8 July 2022

The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45316946)

CD28 dependent PI3K/Akt signaling

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