(Q45316963)

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Antigen Presentation: Folding, assembly and peptide loading of class I MHC

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-983170)

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8 July 2022

Class I MHC mediated antigen processing & presentation

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-983170

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8 July 2022

Binding of newly synthesized MHC class I heavy chain (HC) with calnexin

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8 July 2022

Interaction of Erp57 with MHC class I HC

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8 July 2022

Interaction of beta-2-microglobulin (B2M) chain with class I HC

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8 July 2022

Formation of peptide loading complex (PLC)

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8 July 2022

Transport of Antigen peptide in to ER

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8 July 2022

Trimming of peptides in ER

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8 July 2022

Loading of antigenic peptides on to class I MHC

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8 July 2022

Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex

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8 July 2022

Transport of MHC heterotrimer to ER exit site

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8 July 2022

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8 July 2022

Disassembly of COPII coated vesicle

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8 July 2022

Budding of COPII coated vesicle

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8 July 2022

Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle

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8 July 2022

Capturing cargo and formation of prebudding complex

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8 July 2022

Journey of cargo through Golgi complex

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8 July 2022

Expression of peptide bound class I MHC on cell surface

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8 July 2022

Post-proteasomal antigen processing for major histocompatibility complex class I presentation

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8 July 2022

Molecular mechanisms of MHC class I-antigen processing: redox considerations

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8 July 2022

Assembly and export of MHC class I peptide ligands

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8 July 2022

The known unknowns of antigen processing and presentation.

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8 July 2022

The quality control of MHC class I peptide loading

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45316963)

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

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