(Q35821228)

10 August 2017

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title

Post-proteasomal antigen processing for major histocompatibility complex class I presentation (English)

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antigen processing and presentation of peptide antigen via MHC class I

10 August 2017

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proteolysis by cytosolic proteases associated with antigen processing and presentation

GO:0002474

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proteolysis within endoplasmic reticulum associated with antigen processing and presentation

GO:0002203

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proteasomal proteolysis associated with antigen processing and presentation

GO:0002498

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proteolysis associated with antigen processing and presentation

GO:0002497

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Kenneth L Rock

1

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10 August 2017

Ian A York

series ordinal

2

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10 August 2017

Alfred L Goldberg

series ordinal

3

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10 August 2017

language of work or name

English

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publication date

1 July 2004

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10 August 2017

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10 August 2017

5

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10 August 2017

7

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10 August 2017

670-677

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Degradation of cell proteins and the generation of MHC class I-presented peptides

10 August 2017

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Proteolysis and class I major histocompatibility complex antigen presentation

21 January 2018

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Protein degradation and the generation of MHC class I-presented peptides.

21 January 2018

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Producing nature's gene-chips: the generation of peptides for display by MHC class I molecules

21 January 2018

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Chemistry of peptides associated with MHC class I and class II molecules

21 January 2018

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Quantitating protein synthesis, degradation, and endogenous antigen processing

21 January 2018

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Protein degradation and protection against misfolded or damaged proteins

21 January 2018

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Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.

21 January 2018

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

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Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide

21 January 2018

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The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses

21 January 2018

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Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities

21 January 2018

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Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products

21 January 2018

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26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

21 January 2018

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Efficient identification of novel HLA-A(*)0201-presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis.

21 January 2018

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Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells

21 January 2018

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Cytotoxic T lymphocyte epitopes of HIV-1 Nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes

21 January 2018

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Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I.

21 January 2018

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The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues

21 January 2018

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A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.

21 January 2018

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Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses

21 January 2018

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Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase

21 January 2018

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Peptide size selection by the major histocompatibility complex-encoded peptide transporter

21 January 2018

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Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells

21 January 2018

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The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide

21 January 2018

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Two new proteases in the MHC class I processing pathway

21 January 2018

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Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum

21 January 2018

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Trimming of antigenic peptides in an early secretory compartment

21 January 2018

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Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling

21 January 2018

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Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER.

21 January 2018

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Efficient MHC class I-independent amino-terminal trimming of epitope precursor peptides in the endoplasmic reticulum

21 January 2018

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Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis

21 January 2018

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HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

21 January 2018

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HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation

21 January 2018

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A role for a novel luminal endoplasmic reticulum aminopeptidase in final trimming of 26 S proteasome-generated major histocompatability complex class I antigenic peptides

21 January 2018

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MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum

21 January 2018

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ER aminopeptidases generate a unique pool of peptides for MHC class I molecules.

21 January 2018

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ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

21 January 2018

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Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase

21 January 2018

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Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding

21 January 2018

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Molecular characterization of a puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP

21 January 2018

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An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides

21 January 2018

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Translocation of long peptides by transporters associated with antigen processing (TAP).

21 January 2018

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Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases

21 January 2018

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Cellular peptide composition governed by major histocompatibility complex class I molecules.

21 January 2018

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Three-dimensional structure of a peptide extending from one end of a class I MHC binding site

21 January 2018

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Major histocompatibility complex class I viral antigen processing in the secretory pathway defined by the trans-Golgi network protease furin.

21 January 2018

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Furin at the cutting edge: from protein traffic to embryogenesis and disease

21 January 2018

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Peptide selection by MHC-encoded TAP transporters

21 January 2018

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Multiple proteases process viral antigens for presentation by MHC class I molecules to CD8(+) T lymphocytes

21 January 2018

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Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation

21 January 2018

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An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.

21 January 2018

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Tripeptidyl peptidases: enzymes that count

21 January 2018

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A giant protease with potential to substitute for some functions of the proteasome

21 January 2018

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The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases.

21 January 2018

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Quantifying recruitment of cytosolic peptides for HLA class I presentation: impact of TAP transport

21 January 2018

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The Group II Chaperonin TRiC Protects Proteolytic Intermediates from Degradation in the MHC Class I Antigen Processing Pathway

21 January 2018

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Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase

21 January 2018

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The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation

21 January 2018

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Regulation of cell-surface major histocompatibility complex class I expression by the endopeptidase EC3.4.24.15 (thimet oligopeptidase).

21 January 2018

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Review: cellular substrates of the eukaryotic chaperonin TRiC/CCT.

21 January 2018

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An endogenous HIV envelope-derived peptide without the terminal NH3+ group anchor is physiologically presented by major histocompatibility complex class I molecules

21 January 2018

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The signal sequence of lymphocytic choriomeningitis virus contains an immunodominant cytotoxic T cell epitope that is restricted by both H-2D(b) and H-2K(b) molecules

21 January 2018

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Thimet oligopeptidase and oligopeptidase M or neurolysin.

21 January 2018

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The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

21 January 2018

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The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

21 January 2018

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7 January 2021

Proteolytic processing of peptides in the lumen of the endoplasmic reticulum for antigen presentation by major histocompatibility class I

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7 January 2021

TAP prefers to transport melanoma antigenic peptides which are longer than the optimal T-cell epitope: evidence for further processing in the endoplasmic reticulum

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7 January 2021

Is antigen processing guided by major histocompatibility complex molecules?

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7 January 2021

Generation of MHC class I peptide antigens by protein processing in the secretory route by furin

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7 January 2021

Rapid degradation of an abnormal protein in Escherichia coli proceeds through repeated cycles of association with GroEL

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7 January 2021

Identifiers

DOI

10.1038/NI1089

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10 August 2017

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