(Q35821221)

10 August 2017

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title

Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII. (English)

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10 August 2017

Peter M Kloetzel

1

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PubMed ID

15224091

10 August 2017

language of work or name

English

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publication date

1 July 2004

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10 August 2017

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10 August 2017

5

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10 August 2017

661-669

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10 August 2017

7

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Post-proteasomal antigen processing for major histocompatibility complex class I presentation

10 August 2017

1 reference

The specificity of proteasomes: impact on MHC class I processing and presentation of antigens

21 January 2018

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Protein degradation and the generation of MHC class I-presented peptides.

21 January 2018

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Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

21 January 2018

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A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes

21 January 2018

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Antigen processing by the proteasome

21 January 2018

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Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase

21 January 2018

1 reference

Two new proteases in the MHC class I processing pathway

21 January 2018

1 reference

The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation

21 January 2018

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Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase

21 January 2018

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A giant protease with potential to substitute for some functions of the proteasome

21 January 2018

1 reference

An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.

21 January 2018

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ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

21 January 2018

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An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides

21 January 2018

1 reference

Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases

21 January 2018

1 reference

Efficient MHC class I-independent amino-terminal trimming of epitope precursor peptides in the endoplasmic reticulum

21 January 2018

1 reference

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

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The 26S proteasome: a molecular machine designed for controlled proteolysis

21 January 2018

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Structure of 20S proteasome from yeast at 2.4 A resolution

21 January 2018

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A gated channel into the proteasome core particle

21 January 2018

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Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids.

21 January 2018

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Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity.

21 January 2018

1 reference

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

21 January 2018

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Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1.

21 January 2018

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The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release

21 January 2018

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Structure of the proteasome activator REGalpha (PA28alpha)

21 January 2018

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Significance of the rapid degradation of newly synthesized proteins in mammalian cells: a working hypothesis

21 January 2018

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Quantitating protein synthesis, degradation, and endogenous antigen processing

21 January 2018

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Making sense of mass destruction: quantitating MHC class I antigen presentation

21 January 2018

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

21 January 2018

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MHC class I antigen processing of an adenovirus CTL epitope is linked to the levels of immunoproteasomes in infected cells

21 January 2018

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The cleavage preference of the proteasome governs the yield of antigenic peptides.

21 January 2018

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Characteristics of HIV-1 Nef regions containing multiple CD8+ T cell epitopes: wealth of HLA-binding motifs and sensitivity to proteasome degradation

21 January 2018

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Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex

21 January 2018

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Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport

21 January 2018

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21 January 2018

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DNA sequence, chromosomal localization, and tissue expression of the mouse proteasome subunit lmp10 (Psmb10) gene

21 January 2018

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Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits

21 January 2018

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The subunits MECL-1 and LMP2 are mutually required for incorporation into the 20S proteasome

21 January 2018

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Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits

21 January 2018

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Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes

21 January 2018

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Identification and characterization of a mammalian protein interacting with 20S proteasome precursors

21 January 2018

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Expression and subcellular localization of mouse 20S proteasome activator complex PA28

21 January 2018

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Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta.

21 January 2018

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Impaired immunoproteasome assembly and immune responses in PA28-/- mice.

21 January 2018

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A role for the proteasome regulator PA28alpha in antigen presentation

21 January 2018

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Phosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon

21 January 2018

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Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products

21 January 2018

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Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

21 January 2018

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Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

21 January 2018

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LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes.

21 January 2018

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Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes

21 January 2018

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Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28

21 January 2018

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Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope

21 January 2018

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Altered peptidase and viral-specific T cell response in LMP2 mutant mice.

21 January 2018

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Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 20S mouse proteasomes

21 January 2018

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The human 26 S and 20 S proteasomes generate overlapping but different sets of peptide fragments from a model protein substrate.

21 January 2018

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Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells

21 January 2018

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Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome

21 January 2018

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26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

21 January 2018

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Assessment of proteasomal cleavage probabilities from kinetic analysis of time-dependent product formation

21 January 2018

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Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes.

21 January 2018

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The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide

21 January 2018

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Immunoproteasomes largely replace constitutive proteasomes during an antiviral and antibacterial immune response in the liver

21 January 2018

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Link between organ-specific antigen processing by 20S proteasomes and CD8(+) T cell-mediated autoimmunity

21 January 2018

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Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings

21 January 2018

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Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis

21 January 2018

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Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing

21 January 2018

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Lysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta.

21 January 2018

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Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28.

21 January 2018

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Structural basis for the activation of 20S proteasomes by 11S regulators

21 January 2018

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Reconstitution of hybrid proteasomes from purified PA700-20 S complexes and PA28alphabeta activator: ultrastructure and peptidase activities

21 January 2018

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The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes.

21 January 2018

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cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome

21 January 2018

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PI31 is a modulator of proteasome formation and antigen processing

21 January 2018

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Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type

21 January 2018

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Tripeptidyl peptidases: enzymes that count

21 January 2018

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The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases.

21 January 2018

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A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.

21 January 2018

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Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity

21 January 2018

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Taking a bite: proteasomal protein processing

21 January 2018

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

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Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a nonprocessive pathway

21 January 2018

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Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I.

21 January 2018

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21 January 2018

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The major substrates for TAP in vivo are derived from newly synthesized proteins

21 January 2018

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MHC-linked LMP gene products specifically alter peptidase activities of the proteasome

21 January 2018

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The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells

21 January 2018

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Proteolysis and class I major histocompatibility complex antigen presentation

21 January 2018

1 reference

7 January 2021

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

1 reference

7 January 2021

The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

1 reference

7 January 2021

Interferon-gamma induces different subunit organizations and functional diversity of proteasomes

1 reference

7 January 2021

Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands

1 reference

7 January 2021

Double-cleavage production of the CTL epitope by proteasomes and PA28: role of the flanking region

1 reference

7 January 2021

Incorporation of major histocompatibility complex--encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon-gamma

1 reference

7 January 2021

Dendritic cells up-regulate immunoproteasomes and the proteasome regulator PA28 during maturation

1 reference

7 January 2021

Lysozyme degradation by the bovine multicatalytic proteinase complex (proteasome): evidence for a nonprocessive mode of degradation

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7 January 2021

Identifiers

DOI

10.1038/NI1090

1 reference

10 August 2017

1 reference

PubMed ID

15224091