(Q33187465)

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The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

allosteric inhibitor

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Alexei F Kisselev

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Margarita Garcia-Calvo

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Herman S Overkleeft

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Erin Peterson

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Nancy A Thornberry

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Alfred L Goldberg

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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18 June 2003

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Journal of Biological Chemistry

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

278

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

38

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4 November 2019

35869-35877

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12815064%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1 reference

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The proteasome: paradigm of a self-compartmentalizing protease

1 reference

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The 26S proteasome: a molecular machine designed for controlled proteolysis

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Structure of 20S proteasome from yeast at 2.4 A resolution

1 reference

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The multicatalytic proteinase complex, a major extralysosomal proteolytic system

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Why does threonine, and not serine, function as the active site nucleophile in proteasomes?

1 reference

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Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution

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Proteasome from Thermoplasma acidophilum: a threonine protease

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The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic study

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Conformational constraints for protein self-cleavage in the proteasome

1 reference

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21 January 2018

A gated channel into the proteasome core particle

1 reference

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21 January 2018

The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release

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21 January 2018

Structural basis for the activation of 20S proteasomes by 11S regulators

1 reference

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21 January 2018

Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings

1 reference

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21 January 2018

Lack of proteasome active site allostery as revealed by subunit-specific inhibitors

1 reference

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21 January 2018

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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21 January 2018

Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin

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Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

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21 January 2018

Definition of the extended substrate specificity determinants for beta-tryptases I and II.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303725200

21 January 2018

Substrate specificity of the human proteasome

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303725200

21 January 2018

Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303725200

21 January 2018

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303725200

21 January 2018

Cleavage of Pro-X and Glu-X bonds catalyzed by the branched chain amino acid preferring activity of the bovine pituitary multicatalytic proteinase complex (20S proteasome).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303725200

21 January 2018

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

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21 January 2018

Inhibition of human caspases by peptide-based and macromolecular inhibitors

1 reference

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21 January 2018

A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

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21 January 2018

Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation

1 reference

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21 January 2018

Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants

1 reference

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21 January 2018

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids.

1 reference

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21 January 2018

Components of the bovine pituitary multicatalytic proteinase complex (proteasome) cleaving bonds after hydrophobic residues.

1 reference

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21 January 2018

Proteasome inhibitors: from research tools to drug candidates

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Degradation of cell proteins and the generation of MHC class I-presented peptides

1 reference

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26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

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Lysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta.

1 reference

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Bovine spleen multicatalytic proteinase complex (proteasome). Replacement of X, Y, and Z subunits by LMP7, LMP2, and MECL1 and changes in properties and specificity.

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21 January 2018

The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing

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21 January 2018

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