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An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
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scholarly article
1 reference
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PubMed
PubMed ID
12436109
retrieved
4 January 2017
title
An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides
(English)
1 reference
stated in
PubMed
PubMed ID
12436109
retrieved
4 January 2017
author name string
Tomo Saric
series ordinal
1
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PubMed
PubMed ID
12436109
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4 January 2017
Shih-Chung Chang
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2
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PubMed
PubMed ID
12436109
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4 January 2017
Akira Hattori
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3
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PubMed
PubMed ID
12436109
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4 January 2017
Ian A. York
series ordinal
4
1 reference
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PubMed
PubMed ID
12436109
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4 January 2017
Shirley Markant
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5
1 reference
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PubMed
PubMed ID
12436109
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4 January 2017
Kenneth L. Rock
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6
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PubMed
PubMed ID
12436109
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4 January 2017
Masafumi Tsujimoto
series ordinal
7
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PubMed
PubMed ID
12436109
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4 January 2017
Alfred L. Goldberg
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8
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PubMed
PubMed ID
12436109
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4 January 2017
language of work or name
English
0 references
publication date
1 December 2002
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PubMed
PubMed ID
12436109
retrieved
4 January 2017
published in
Nature Immunology
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PubMed
PubMed ID
12436109
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4 January 2017
volume
3
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PubMed
PubMed ID
12436109
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4 January 2017
page(s)
1169–1176
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PubMed
PubMed ID
12436109
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4 January 2017
issue
12
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PubMed
PubMed ID
12436109
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4 January 2017
cites work
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
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inferred from DOI database lookup
Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
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7 January 2021
based on heuristic
inferred from DOI database lookup
The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
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7 January 2021
based on heuristic
inferred from DOI database lookup
The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Degradation of cell proteins and the generation of MHC class I-presented peptides
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxic T lymphocyte epitopes of HIV-1 Nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
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7 January 2021
based on heuristic
inferred from DOI database lookup
26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
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7 January 2021
based on heuristic
inferred from DOI database lookup
Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ER aminopeptidases generate a unique pool of peptides for MHC class I molecules.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The murine cytomegalovirus pp89 immunodominant H-2Ld epitope is generated and translocated into the endoplasmic reticulum as an 11-mer precursor peptide
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FNI859
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
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7 January 2021
based on heuristic
inferred from DOI database lookup
Two new proteases in the MHC class I processing pathway
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reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
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7 January 2021
based on heuristic
inferred from DOI database lookup
Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
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7 January 2021
based on heuristic
inferred from DOI database lookup
Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteolytic processing of peptides in the lumen of the endoplasmic reticulum for antigen presentation by major histocompatibility class I
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Trimming of antigenic peptides in an early secretory compartment
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficient MHC class I-independent amino-terminal trimming of epitope precursor peptides in the endoplasmic reticulum
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A role for a novel luminal endoplasmic reticulum aminopeptidase in final trimming of 26 S proteasome-generated major histocompatability complex class I antigenic peptides
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal sequence processing in rough microsomes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular peptide composition governed by major histocompatibility complex class I molecules.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An endoplasmic reticulum protein implicated in chaperoning peptides to major histocompatibility of class I is an aminopeptidase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GRP94-associated enzymatic activities. Resolution by chromatographic fractionation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular characterization of a puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mouse orthologue of puromycin-insensitive leucyl-specific aminopeptidase is expressed in endothelial cells and plays an important role in angiogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis for the activation of 20S proteasomes by 11S regulators
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preparation of microsomal membranes for cotranslational protein translocation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNI859
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/NI859
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4147335
OpenCitations bibliographic resource ID
4147335
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4147335
PubMed ID
12436109
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4147335
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