(Q45317229)

English

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2162123)

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cyclooxygenase pathway

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Arachidonic acid metabolism

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https://identifiers.org/reactome:R-HSA-2162123

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PTGS2 dimer binds PTGS2 inhibitors

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ASA- acetylates PTGS1

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ASA- acetylates PTGS2

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Arachidonic acid is oxidised to PGG2 by PTGS1

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Arachidonic acid is oxidised to PGG2 by PTGS2

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PGG2 is reduced to PGH2 by PTGS1

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PGG2 is reduced to PGH2 by PTGS2

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PGH2 diffuses from the endoplasmic reticulum lumen to the cytosol

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PGH2 is reduced to PGF2a by AKR1C3

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PGH2 is reduced to PGF2a by FAM213B

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PGH2 is isomerised to PGE2 by PTGES

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Prostaglandin E synthase isomerizes PGH2 to PGE2

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PGE2 is converted to PGF2a by CBR1

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PGE2 is dehydrated to PGA2

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PGA2 is isomerised to PGC2

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PGC2 is isomerised to PGB2

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PGA2 is dehydrated to 15d-PGA2

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PGH2 is isomerised to PGD2 by PTGDS

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PGH2 is isomerised to PGD2 by HPGDS

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PGD2 is dehydrated to PGJ2

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PGJ2 is isomerised to delta12-PGJ2

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Delta12-PGJ2 is dehydrated to 15d-PGJ2

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PGD2 is dehydrated to 15d-PGD2

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PGD2 is reduced to 11-epi-PGF2a by AKRIC3

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PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD

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15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1

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PTGIS, CYP8A1 isomerise PGH2 to PGI2

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PGI2 is hydrolysed to 6k-PGF1a

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TBXAS1 isomerises PGH2 to TXA2

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TXA2 is hydrolysed to TXB2

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TXB2 is converted to 11dh-TXB2 by TXDH

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PGH2 is degraded to 12S-HHT and MDA by TBXAS1

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PTGS1 dimer binds PTGS1 Inhibitors

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Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology

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8 July 2022

Old and new generation lipid mediators in acute inflammation and resolution

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8 July 2022

Identifiers

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8 July 2022

(Q45317229)

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

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