(Q45317351)

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Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-381676)

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8 July 2022

regulation of insulin secretion

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8 July 2022

Regulation of insulin secretion

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8 July 2022

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https://identifiers.org/reactome:R-HSA-381676

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GLP1R:GLP1 activates G(s)

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Heterotrimeric G(s) complex dissociates

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G(s):GTP activates Adenylyl cyclase

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Activated Adenylyl cyclase synthesizes cyclic AMP

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PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP

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Potassium voltage-gated channels close in reponse to PKA

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ER calcium channels open in response to activated PKA

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RAP1A exchanges GDP for GTP

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GLP1R binds GLP1R agonists

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The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion

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Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion

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Mechanisms of action of glucagon-like peptide 1 in the pancreas

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Triggering and amplifying pathways of regulation of insulin secretion by glucose

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Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

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Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting beta TC3 cells

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8 July 2022

G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes.

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8 July 2022

Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45317351)

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

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