(Q45317343)

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Regulation of insulin secretion

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-422356)

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8 July 2022

regulation of insulin secretion

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8 July 2022

Integration of energy metabolism

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8 July 2022

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https://identifiers.org/reactome:R-HSA-422356

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Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

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Acetylcholine regulates insulin secretion

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Adrenaline,noradrenaline inhibits insulin secretion

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Free fatty acids regulate insulin secretion

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IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel

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IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol

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Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2

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KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel

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Calcium Influx through Voltage-gated Calcium Channels

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Exocytosis of Insulin

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SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer)

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Meglitinides bind ABCC8

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Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion

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Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes

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Triggering and amplifying pathways of regulation of insulin secretion by glucose

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8 July 2022

Minireview: implication of mitochondria in insulin secretion and action

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45317343)

Regulation of insulin secretion

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