(Q50294391)

English

KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-265682)

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8 July 2022

Regulation of insulin secretion

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-265682

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KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane]

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KCNJ11:ATP tetramer:ABCC8 tetramer [plasma membrane]

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KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane]

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PKA catalytic subunit [cytosol]

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RAPGEF4:cAMP Complex [plasma membrane]

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8 July 2022

RAPGEF3:cAMP complex [plasma membrane]

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8 July 2022

1

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8 July 2022

1

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8 July 2022

Two regions of sulfonylurea receptor specify the spontaneous bursting and ATP inhibition of KATP channel isoforms

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8 July 2022

Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice

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8 July 2022

A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels

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8 July 2022

Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y.

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8 July 2022

Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel

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8 July 2022

Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations

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8 July 2022

Inwardly rectifying potassium channels: their structure, function, and physiological roles

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8 July 2022

Triggering and amplifying pathways of regulation of insulin secretion by glucose

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8 July 2022

Minireview: implication of mitochondria in insulin secretion and action

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8 July 2022

Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development.

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8 July 2022

Action potentials and insulin secretion: new insights into the role of Kv channels

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8 July 2022

A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults

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8 July 2022

The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells

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8 July 2022

Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q50294391)

KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel

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