(Q45317365)

English

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1474151)

In more languages

edit

Statements

1 reference

8 July 2022

tetrahydrobiopterin metabolic process

1 reference

8 July 2022

Metabolism of cofactors

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-1474151

1 reference

8 July 2022

GCH1 reduces GTP to dihydroneopterin triphosphate

1 reference

8 July 2022

PTPS is phosphorylated by cGMP-dependant protein kinase II

1 reference

8 July 2022

DHNTP is dephosphorylated by PTPS to PTHP

1 reference

8 July 2022

Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II

1 reference

8 July 2022

PTHP is reduced to BH4 by sepiapterin reductase (SPR)

1 reference

8 July 2022

BH4 is oxidised to the BH3 radical during the eNOS catalytic cycle

1 reference

8 July 2022

Peroxynitrite can oxidise BH4 to the BH3 radical

1 reference

8 July 2022

Ferrous iron reduces the BH3 radical back to BH4

1 reference

8 July 2022

Ascorbate can reduce the BH3 radical back to BH4

1 reference

8 July 2022

The BH3 radical can decay to dihydrobiopterin (BH2)

1 reference

8 July 2022

BH2 binding can lead to eNOS uncoupling

1 reference

8 July 2022

GCHFR binds to GCH1 and negatively regulates its activity

1 reference

8 July 2022

Salvage - Sepiapterin is reduced to BH2

1 reference

8 July 2022

Salvage - BH2 is reduced to BH4 by DHFR

1 reference

8 July 2022

The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle

1 reference

8 July 2022

Unknown sepiapterin synthase transforms PTHP to sepiapterin

1 reference

8 July 2022

Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease

1 reference

8 July 2022

Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension

1 reference

8 July 2022

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease

1 reference

8 July 2022

Tetrahydrobiopterin biosynthesis, regeneration and functions

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q45317365)

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)