(Q45317588)

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Synthesis of wybutosine at G37 of tRNA(Phe)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6782861)

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8 July 2022

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8 July 2022

tRNA modification in the nucleus and cytosol

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-6782861

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8 July 2022

TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)

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8 July 2022

TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)

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8 July 2022

TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)

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8 July 2022

TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)

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8 July 2022

LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)

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8 July 2022

LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe)

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8 July 2022

TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)

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8 July 2022

LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)

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8 July 2022

Wybutosine biosynthesis: structural and mechanistic overview

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8 July 2022

Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine

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8 July 2022

Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions

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8 July 2022

Role of a tRNA base modification and its precursors in frameshifting in eukaryotes

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45317588)

Synthesis of wybutosine at G37 of tRNA(Phe)

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