(Q45317586)

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tRNA modification in the nucleus and cytosol

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6782315)

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https://identifiers.org/reactome:R-HSA-6782315

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Synthesis of wybutosine at G37 of tRNA(Phe)

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ADAT1 deaminates adenosine-37 in tRNA(Ala)

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ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs

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ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34

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CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37

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CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs

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DUS2:EPRS reduces uridine to dihydrouridine in tRNAs

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EKC complex threonylcarbamoylates A37 of tRNAs

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KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine

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METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46

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NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)

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NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)

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NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)

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NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)

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PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs

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PUS3 transforms uridine-39 to pseudouridine-39 in tRNA

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PUS7 transforms uridine to pseudouridine in tRNAs

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QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr)

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TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)

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THG1L transfers GMP to 5' end of tRNA(His)

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TRIT1 transfers dimethylallyl group to adenosine-37 of tRNAs

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TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)

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TRMT10A methylates guanosine-9 in tRNA

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TRMT11:TRMT112 methylates guanosine-10 in tRNA

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TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)

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TRMT13 2'-O-methylates cytidine-4 in tRNA

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TRMT13 2'-O-methylates adenosine-4 in tRNA

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TRMT44 2'-O-methylates uridine-44 in tRNA(Ser)

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FTSJ1 2'-O-methylates cytidine-32 in tRNA(Phe)

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FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe)

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tRNA modifications regulate translation during cellular stress

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Chemistry enters nucleic acids biology: enzymatic mechanisms of RNA modification

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8 July 2022

Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical Legoland

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8 July 2022

Transfer RNA modifications: nature's combinatorial chemistry playground.

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8 July 2022

Modify or die?--RNA modification defects in metazoans

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The pivotal regulatory landscape of RNA modifications

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Role of tRNA modifications in human diseases

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Post-transcriptional modifications to tRNA--a response to the genetic code degeneracy

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8 July 2022

Identifiers

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8 July 2022

(Q45317586)

tRNA modification in the nucleus and cytosol

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