(Q50295912)

English

ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-6786500)

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Statements

biological process

1 reference

8 July 2022

tRNA modification

1 reference

8 July 2022

tRNA modification in the nucleus and cytosol

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-6786500

1 reference

8 July 2022

tRNA(Arg,Glu) containing 5-carboxymethylU-34 [cytosol]

1

object has role

1 reference

8 July 2022

tRNA(Arg,Glu) containing 5-methoxycarbonylmethylU-34 [cytosol]

1

object has role

1 reference

8 July 2022

ALKBH8:Fe2+ [cytosol]

1

object has role

1 reference

8 July 2022

S-Adenosylmethionine(1+, zwitterion)

1

object has role

1 reference

8 July 2022

S-adenosyl-L-homocysteine zwitterion

1

object has role

1 reference

8 July 2022

Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival

1 reference

8 July 2022

Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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